دانلود کتاب Biocatalysis for the Pharmaceutical Industry: Discovery, Development, and Manufacturing

Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.Content: Chapter 1 Enzymes and Their Synthetic Applications: An Overview (pages 1–19): Junhua (Alex) Tao and Jian?He XuChapter 2 Expression Hosts for Enzyme Discovery and Production (pages 21–44): Aleksandra Andryushkova and Anton GliederChapter 3 Directed Enzyme Evolution and High?Throughput Screening (pages 45–64): Michael J. McLachlan, Ryan P. Sullivan and Huimin ZhaoChapter 4 Applications of Reaction Engineering to Industrial Biotransformations (pages 65–88): Lutz Hilterhaus and Andreas LieseChapter 5 Chiral Synthesis of Pharmaceutical Intermediates Using Oxynitrilases (pages 89–109): Wen?Ya Lu and Guo?Qiang LinChapter 6 Expanding the Scope of Aldolases as Tools for Organic Synthesis (pages 111–119): William A. GreenbergChapter 7 Synthetic Applications of Ketoreductases and Alcohol Oxidases (pages 121–151): Dunming Zhu and Ling HuaChapter 8 Applications of Nitrile Hydratases and Nitrilases (pages 153–181): Grace DeSantis and Robert DiCosimoChapter 9 Biosynthesis of Drug Metabolites (pages 183–211): Wenying Li, David Rozzell, Spiros Kambourakis and Martin MayhewChapter 10 Application of Whole?Cell Biotransformation in the Pharmaceutical Industry (pages 213–227): Kin Sing LamChapter 11 Combinatorial Biosynthesis of Pharmaceutical Natural Products (pages 229–245): Wen Liu and Yi YuChapter 12 Metabolic Engineering for the Development and Manufacturing of Pharmaceuticals (pages 247–271): Dongping Lu, Philip G. Williams and Guangyi WangChapter 13 Multimodular Synthases and Supporting Enzymes for Chemical Production (pages 273–303): Michael Burkart and Junhua (Alex) TaoChapter 14 Green Chemistry with Biocatalysis for Production of Pharmaceuticals (pages 305–321): Oliver May