دانلود کتاب Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment

Content: Parameters for pesticide QSAR and PBPK/PD models to inform human risk assessments -- Chiral chemistry and toxicity assessments for pyrethroid pesticides -- Direct chiral separation of pyrethroid isomers by HPLC with chiral stationary phases -- Biotransformation and enzymes responsible for metabolism of pyrethroids in mammals -- Characterization of potential age-related differences in pyrethroid pharmacokinetics -- 15 factors of percutaneous penetration of pesticides -- Percutaneous absorption of pesticide formulations -- Human metabolic interactions of pesticides : inhibition, induction and activation -- Paraoxonase 1 (PON1) status in risk assessment for organophosphate exposure and pharmacokinetics -- Carboxylesterases : a multifunctional enzyme involved in pesticide and lipid metabolism -- Behavioral changes in adult and young rats as indications of cholinesterase inhibition -- Comparison of esterase sensitivity, metabolic efficiency, and toxicity levels of two organophosphorus insecticides, parathion and chlorpyrifos -- Regional brain dosimetry for the organophosphorus insecticide chlorpyrifos in the preweanling rat -- Pyrethroid actions on sodium channels : isoform and species specificity -- In vitro and in vivo experimental data for development and use of pharmacokinetic models for in vitro to in vivo extrapolation of pyrethroid insecticides -- In silico strategies for modeling stereoselective metabolism of pyrethroids -- Quantitative structure-activity relationships for organophosphate enzyme inhibition -- Computational approaches for developing informative prior distributions for bayesian calibration of PBPK models -- Use of cytochrome P450-specific parameters and human biomarker data to develop a human physiologically based pharmacokinetic/pharmacodynamic model for dermal chlorpyrifos exposure -- Use of in vitro data in PBPK models : an example of in vitro to in vivo extrapolation with carbaryl.