دانلود کتاب Neuroimaging in Multiple Sclerosis (Neurology-laboratory and Clinical Research Developments)

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease that affects the whole brain. Neuroimaging techniques that can help elucidate and characterize the nature and mechanism of tissue injury and disease progression in MS are of particular importance, given their roles in seeking successful preventive and therapeutic treatments for the disease. Imaging biomarkers of MS include multiple lesions, brain atrophy and normal appearing brain tissue abnormalities. Although MS is considered to be an autoimmune inflammatory disease that primarily activates hematogenous macrophages that destroy myelin, growing evidence strongly suggests that MS is a diffused neurodegenerative disease. Imaging myelin in the brain has great potential in revealing the myelination and maturation process in the brain, and can help further explain the link between the initial inflammatory event and subsequent degenerative processes of the disease. While myelin is most abundant in white matter, forefron