دانلود کتاب Analysis of Aggregates and Particles in Protein Pharmaceuticals

Content: Chapter 1 The Critical Need for Robust Assays for Quantitation and Characterization of Aggregates of Therapeutic Proteins (pages 1–7): John F. Carpenter, Barry Cherney and Amy S. RosenbergChapter 2 Separation?Based Analytical Methods for Measuring Protein Aggregation (pages 9–36): Jun Liu, Barthelemy Demeule and Steven J. ShireChapter 3 Laser Light Scattering?Based Techniques Used for the Characterization of Protein Therapeutics (pages 37–60): John den Engelsman, Fabian Kebbel and Patrick GaridelChapter 4 Online Detection Methods and Emerging Techniques for Soluble Aggregates in Protein Pharmaceuticals (pages 61–84): Tapan K. DasChapter 5 Analytical Methods to Measure Subvisible Particulates (pages 85–115): Shawn Cao, Linda Narhi, Yijia Jiang and Rahul S. RajanChapter 6 Detection of Visible Particles in Parenteral Products (pages 117–132): Ronald Smulders, Hans Vos and Hanns?Christian MahlerChapter 7 Characterization of Aggregates and Particles Using Emerging Techniques (pages 133–167): Hui Zhao, Manuel Diez, Atanas Koulov, Mariola Bozova, Markus Bluemel and Kurt ForrerChapter 8 Ultraviolet Absorption Spectroscopy (pages 169–200): Reza Esfandiary and Charles Russell MiddaughChapter 9 Fluorescence Spectroscopy to Characterize Protein Aggregates and Particles (pages 201–226): Robert A. Poole, Andrea Hawe, Wim Jiskoot and Kevin BraeckmansChapter 10 Infrared Spectroscopy to Characterize Protein Aggregates (pages 227–248): Marco van de Weert and Lene JorgensenChapter 11 Raman Microscopy for Characterization of Particles (pages 249–267): Stefan Fischer, Oliver Valet and Markus LankersChapter 12 Microscopic Methods for Particle Characterization in Protein Pharmaceuticals (pages 269–302): Patrick Garidel, Andrea Herre and Werner KlicheChapter 13 Comparison of Methods for Soluble Aggregate Detection and Size Characterization (pages 303–333): John S. PhiloChapter 14 Protein Purification and its Relation to Protein Aggregation and Particles (pages 335–367): Roberto Falkenstein, Stefan Hepbildikler, Wolfgang Kuhne, Thorsten Lemm, Hans Rogl, Eva Rosenberg, Gerhard Winter, Frank Zettl and Ralf ZippeliusChapter 15 Formulation Development and its Relation to Protein Aggregation and Particles (pages 369–387): Miriam Printz and Wolfgang Friess