دانلود کتاب Bioactive Heterocyclic Compound Classes: Pharmaceuticals

The chemistry of heterocycles is an important branch of organic chemistry. This is due to the fact that a large number of natural products, e. g. hormones, antibiotics, vitamins, etc. are composed of heterocyclic structures. Often, these compounds show beneficial properties and are therefore applied as pharmaceuticals to treat diseases or as insecticides, herbicides or fungicides in crop protection. This volume presents important pharmaceuticals. Each of the 20 chapters covers in a concise manner one class of heterocycles, clearly structuredas follows: * Structural formulas of most important examples (market products) * Short background of history or discovery * Typical syntheses of important examples * Mode of action * Characteristic biological activity * Structure-activity relationship * Additional chemistry information (e.g. further transformations, alternative syntheses, metabolic pathways, etc.) * References. A valuable one-stop reference source for researchers in academia and industry as well as for graduate students with career aspirations in the pharmaceutical chemistry.Content: Chapter 1 The Significance of Heterocycles for Pharmaceuticals and Agrochemicals (pages 1–20): Dr. Clemens Lamberth and Dr. Jurgen DingesChapter 2 Tropane?Based Alkaloids as Muscarinic Antagonists for the Treatment of Asthma, Obstructive Pulmonary Disease, and Motion Sickness (pages 21–36): Michael L. Schulte and Craig W. LindsleyChapter 3 Morphinone?Based Opioid Receptor Agonist Analgesics (pages 37–49): Stephanie M. NgChapter 4 Barbituric Acid?Based GABA(A) Receptor Modulators for the Treatment of Sleep Disorder and Epilepsy and as Anesthetics (pages 51–64): Ingo Janser and Romy JanserChapter 5 Phenothiazine?Based Dopamine D2 Antagonists for the Treatment of Schizophrenia (pages 65–79): Cristiana A. ZahariaChapter 6 Arylpiperazine?Based 5?HT1A Receptor Partial Agonists and 5?HT2A Antagonists for the Treatment of Autism, Depression, Anxiety, Psychosis, and Schizophrenia (pages 81–97): Irini Akritopoulou?ZanzeChapter 7 Arylpiperidine?Based Dopamine D2 Antagonists/5?HT2A Antagonists for the Treatment of Autism, Depression, Schizophrenia, and Bipolar Disorder (pages 99–114): Ying WangChapter 8 Dibenzazepine?Based Sodium Channel Blockers for the Treatment of Neuropathic Pain (pages 115–133): Derek W. NelsonChapter 9 Dihydropyridine?Based Calcium Channel Blockers for the Treatment of Angina Pectoris and Hypertension (pages 135–151): Milan BrunckoChapter 10 Tetrazole?Based Angiotensin II Type 1 (AT1) Antagonists for the Treatment of Heart Failure and Congestive Hypertension (pages 153–167): Edward C. Lawson, Brian C. Shook and James C. LanterChapter 11 Thiazide?Based Diuretics for the Treatment of Hypertension and Genitourinary Disorders (pages 169–182): Dr. Jurgen DingesChapter 12 Tetrahydropyranone?Based HMG?CoA Reductase Inhibitors for the Treatment of Arterial Hypercholesterolemia (pages 183–200): Hongyu ZhaoChapter 13 Adenine?Based Reverse Transcriptase Inhibitors as Anti?HIV Agents (pages 201–216): Alastair DonaldChapter 14 Guanine?Based Nucleoside Analogs as Antiviral Agents (pages 217–236): Maurizio FranziniChapter 15 Penicillin and Cephalosporin Antibiotics (pages 237–253): Michael Z. HoemannChapter 16 Pyrimidine?Based Kinase Inhibitors in Cancer Chemotherapy (pages 255–273): Robert MahChapter 17 Benzyl Triazole?Based Aromatase Inhibitors for the Treatment of Breast Cancer (pages 275–287): Dawn George and Stacy Van EppsChapter 18 Acetonide?Based Glucocorticoids for the Treatment of Asthma, Skin Inflammation, and Diseases of the Eye (pages 289–312): Kevin P. Cusack, Vikram G. Kalthod, Rajarathnam E. Reddy and Sanjay R. ChemburkarChapter 19 Benzimidazole?Based H+/K+?ATPase Inhibitors for the Treatment of Gastroesophageal Reflux Disease (pages 313–326): Steve SwannChapter 20 Thiazolidinedione?Based Insulin Sensitizers:PPAR?? Agonists for the Treatment of Type 2 Diabetes (pages 327–347): Steven Richards