دانلود کتاب Carbohydrate-Based Vaccines and Immunotherapies

The fundamental science and the latest developments in carbohydrate-based vaccines The relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines and Immunotherapies comprehensively reviews the state of this exciting field, offering a single source for both the fundamental science and the latest developments. With contributions by leading experts, this resource covers the design, synthesis, evaluation, and applications of various carbohydrate-based vaccines, including polysaccharides, neoglycoproteins, and neoglycolipids. The text approaches vaccine design from a chemical and molecular focus, staying in line with current advances. Key topics covered by Carbohydrate-Based Vaccines and Immunotherapies include: Recent developments towards clinically useful vaccines against bacteria, viruses, parasites, and fungi Using adjuvants to improve immunogenicity and/or immunological properties of vaccines Choosing and designing proper adjuvants for specific targets Abnormal carbohydrates expressed by tumors Carbohydrate-based therapeutic cancer vaccines or cancer immunotherapy Clinical trials results for synthetic cancer vaccines Glycoengineering of cell surface carborhydrates and its anticancer applications Using cell surface carbohydrates for disease diagnosis A single, convenient source of state-of-the-art information from leading authorities in the field, Carbohydrate-Based Vaccines and Immunotherapies is an essential reference for organic chemists and biochemists, academic researchers, and other students and professionals involved in vaccine design.Content: Chapter 1 Glycobiology and Immunology (pages 1–53): Udayanath Aich and Kevin J. YaremaChapter 2 Preparation of Glycoconjugate Vaccines (pages 55–88): Wei Zou and Harold J. JenningsChapter 3 Adjuvants for Protein? and Carbohydrate?Based Vaccines (pages 89–115): Bruno GuyChapter 4 Carbohydrate?Based Antibacterial Vaccines (pages 117–166): Robert A. Pon and Harold J. JenningsChapter 5 Carbohydrate?Based Antiviral Vaccines (pages 167–193): Benjamin M. Swarts and Zhongwu GuoChapter 6 Carbohydrate?Based Antiparasitic Vaccines (pages 195–214): Faustin Kamena, Xinyu Liu and Peter H. SeebergerChapter 7 Carbohydrate?Based Antifungal Vaccines (pages 215–226): Magdia De Jesus, Liise?Anne Pirofski and Arturo CasadevallChapter 8 Cancer?Associated and Related Glycosphingolipid Antigens (pages 227–262): Steven B. LeveryChapter 9 Semisynthetic and Fully Synthetic Carbohydrate?Based Cancer Vaccines (pages 263–311): Therese Buskas, Pamela Thompson and Geert?Jan BoonsChapter 10 Glycoengineering of Cell Surface Sialic Acid and Its Application to Cancer Immunotherapy (pages 313–331): Zhongwu GuoChapter 11 Therapeutic Cancer Vaccines: Clinical Trials and Applications (pages 333–366): Hans H. Wandall and Mads A. TarpChapter 12 Carbohydrates as Unique Structures for Disease Diagnosis (pages 367–394): Kate Rittenhouse?Olson