دانلود کتاب Medicinal Natural Products: A Biosynthetic Approach, Second Edition

Medicinal Natural Products, Second Edition is a comprehensive guide providing information on all classes of natural products in medicine. It builds upon fundamental chemical principles and demonstrates a unique integration of plant, microbial and animal natural products in one volume. The text guides the reader through a wealth of diverse natural metabolites used in medicine with sources, production methods, use as drugs and modes of action all extensively covered. Taking a chemistry based approach it combines traditional pharmacognosy with medicinal chemistry. The structure is user-friendly and includes the acclaimed grey boxes on groups of products and detailed mechanistic explanations. * Adopts a novel biosynthetic theme rather than a traditional descriptive approach * Includes extensive further reading at the end of the chapter * Thoroughly revised and updated to incorporate comprehensive coverage of plant, microbial and animal products * Includes the latest developments in the field * New material on genetic manipulation of biosynthetic pathways and non-mevalonate pathway to terpanoids * User-friendly format including extensive use of chemical schemes with annotated mechanistic explanations Content: Chapter 1 About this Book, and How to Use it (pages 1–5): Chapter 2 Secondary Metabolism: The Building Blocks and Construction Mechanisms (pages 7–34): Chapter 3 The Acetate Pathway: Fatty Acids and Polyketides (pages 35–120): Chapter 4 The Shikimate Pathway: Aromatic Amino Acids and Phenylpropanoids (pages 121–166): Chapter 5 The Mevalonate and Deoxyxylulose Phosphate Pathways: Terpenoids and Steroids (pages 167–289): Chapter 6 Alkaloids (pages 291–403): Chapter 7 Peptides, Proteins, and Other Amino Acid Derivatives (pages 405–464): Chapter 8 Carbohydrates (pages 465–486):