دانلود کتاب C-H and C-X bond functionalization : transition metal mediation

Cross-coupling reactions involving C-H and C-X bond functionalisation are commonplace in natural product synthesis and natural products, therapeutic agents, biological probes, and advanced materials. Much attention has been given to understanding the mechanistic strategies used to achieve this, making this a hot topic in recent years.In this edited book, contributions from across the globe examine these strategies, with a particular focus on palladium and copper, as well as iron ₆ an emerging element in this field. Reviewing the recent literature, the book presents an in-depth understanding of the field, guiding the reader to achieving the best synthetic strategies for aromatic functionalisation.Organic and Organometallic chemists, as well as natural product and pharmaceutical scientists, will find this an essential guide to a major transformation currently underway in synthetic chemistry. Read more... Content: Cu-catalyzed Ullmann-type C-heteroatom bond formation: the key role of dinucleating ancillary ligands; Mechanistic understanding of copper-catalyzed aryl-heteroatom bond formation: dependence on ancillary ligands; Fundamental Pd(0)/Pd(II) redox steps in cross-coupling reactions; Pd(II)/Pd(IV) redox catalysis for C-heteroatom bond formation; Mononuclear and Dinuclear Organometallic PdIII complexes in C-C and C-heteroatom bond formation reactions; Aromatic C-F activation: converting toxic substrates to useful synthons. Abstract: This book covers the latest research on transition-metal mediated aromatic C-H and C-X functionalizations with a focus on the two main metals most widely used to achieve cross coupling transformations. Read more...