دانلود کتاب Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders, Second Edition

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology.  In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries.  Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, ?-synuclein and TDP-43) and in the extracellular compartments (e.g. ?-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.Content: Chapter 1 Introduction to Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders (pages 1–5): Dennis W. DicksonChapter 2 Cell Death and Neurodegeneration (pages 6–9): Violetta N. Pivtoraiko and Kevin A. RothChapter 3 Oxidative Stress and Balance in Neurodegenerative Diseases (pages 10–12): George Perry, Siddhartha Mondragon?Rodriguez, Akihiko Nunomura, Xiongwei Zhu, Paula I. Moreira and Mark A. SmithChapter 4 Protein Aggregation in Neurodegeneration (pages 13–17): Adriano Aguzzi and Veronika KanaChapter 5 Protein Degradation in Neurodegeneration: The Ubiquitin Pathway (pages 18–21): Lynn Bedford, Robert Layfield, Nooshin Rezvani, Simon Paine, James Lowe and R. John MayerChapter 6 Genetics of Neurodegeneration (pages 22–25): John HardyChapter 7 Transgenic Animal Models of Proteinopathies (pages 26–36): Naruhiko Sahara, Heather Melrose, Simon D'alton and Jada LewisChapter 8 Clinical Aspects of Alzheimer's Disease (pages 37–50): David KnopmanChapter 9 Genetics of Alzheimer's Disease (pages 51–61): Lars Bertram and Rudolph E. TanziChapter 10 Neuropathology of Alzheimer's Disease and its Variants (pages 62–91): Charles Duyckaerts and Dennis DicksonChapter 11 Amyloid?? Production (pages 92–96): Colin L. Masters and Konrad BeyreutherChapter 12 Elimination of Amyloid ? from the Brain, its Failure in Alzheimer's Disease and Implications for Therapy (pages 97–101): Roy O. Weller, Seth Love and James A. R. NicollChapter 13 Introduction to the Tauopathies (pages 103–109): Michel GoedertChapter 14 Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 (pages 110–134): Bernardino Ghetti, Zbigniew K. Wszolek, Bradley F. Boeve, Salvatore Spina and Michel GoedertChapter 15 Progressive Supranuclear Palsy and Corticobasal Degeneration (pages 135–155): Dennis W. Dickson, Jean?Jaques Hauw, Yves Agid and Irene LitvanChapter 16 Pick's Disease (pages 156–164): David G. Munoz, Huw R. Morris and Martin RossorChapter 17 Argyrophilic Grain Disease (pages 165–170): Markus Tolnay and Heiko BraakChapter 18 Parkinsonism–Dementia Complex of Guam (pages 171–178): Kiyomitsu Oyanagi, Tomoyo Hashimoto and Mineo YamazakiChapter 19 Postencephalitic Parkinsonism (pages 179–187): Kurt A. JellingerChapter 20 Introduction to ??Synucleinopathies (pages 189–193): Maria Grazia SpillantiniChapter 21 Parkinson's Disease (pages 194–223): Kurt A. JellingerChapter 22 Dementia with Lewy Bodies and Parkinson's Disease Dementia (pages 224–237): Paul G. InceChapter 23 Lewy Bodies in Conditions other than Disorders of ??Synuclein (pages 238–241): Coro Paisan?Ruiz, Laura Parkkinen and Tamas ReveszChapter 24 Multiple System Atrophy (pages 242–252): Janice L. Holton, Andrew J. Lees and Tamas ReveszChapter 25 Introduction to Trinucleotide Repeat Diseases (pages 253–257): H. Brent ClarkChapter 26 Huntington's Disease (pages 258–272): John C. Hedreen and Raymund A. C. RoosChapter 27 Spinocerebellar Ataxias (pages 273–287): Hidehiro Mizusawa, H. Brent Clark and Arnulf H. KoeppenChapter 28 Friedreich's Ataxia (pages 288–298): Arnulf H. KoeppenChapter 29 Dentatorubral?Pallidoluysian Atrophy (pages 299–306): Hitoshi Takahashi, Mitsunori Yamada and Shoji TsujiChapter 30 Spinal and Bulbar Muscular Atrophy (pages 307–312): Gen Sobue, Hiroaki Adachi and Masahisa KatsunoChapter 31 Introduction to Prion Disorders (pages 313–321): Adriano Aguzzi and Veronika KanaChapter 32 Sporadic Creutzfeldt–Jakob Disease (pages 322–335): Herbert Budka, Mark W. Head, James W. Ironside, Pierluigi Gambetti, Piero Parchi and Fabrizio TagliaviniChapter 33 Genetic Creutzfeldt–Jakob Disease (pages 336–345): Piero Parchi, Pierluigi Gambetti and Sabina CapellariChapter 34 Fatal Familial and Sporadic Insomnia (pages 346–349): Piero Parchi, Sabina Capellari and Pierluigi GambettiChapter 35 A New Prion Disease: Protease?Sensitive Prionopathy (pages 350–353): Pierluigi Gambetti, Gianfranco Puoti, Qingzhong Kong and Wenquan ZouChapter 36 Variant Creutzfeldt–Jakob Disease (pages 354–363): James W. Ironside, Mark W. Head and Robert G. WillChapter 37 Gerstmann–Straussler–Scheinker Disease (pages 364–377): Bernardino Ghetti, Fabrizio Tagliavini, Gabor G. Kovacs and Pedro PiccardoChapter 38 Kuru (pages 378–380): Catriona Ann McLeanChapter 39 Iatrogenic Creutzfeldt–Jakob Disease (pages 381–386): James W. Ironside, Richard S. G. Knight and Mark W. HeadChapter 40 Introduction (pages 387–392): James LoweChapter 41 Frontotemporal Lobar Degeneration with TDP?43 Pathology (pages 393–403): Ian R. A. Mackenzie and Manuela NeumannChapter 42 Neuronal Intermediate Filament Inclusion Disease (pages 404–411): Nigel J. CairnsChapter 43 Frontotemporal Lobar Degeneration with FUS Immunoreactive Inclusions (pages 412–417): Manuela Neumann and Ian R. A. MackenzieChapter 44 Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis and Spinal Muscular Atrophy (pages 418–433): Michael J. Strong, Tibor Hortobagyi, Koichi Okamoto and Shinsuke KatoChapter 45 Introduction: Genetic Analysis as a Lumper and Splitter in Neurodegenerative Disease (pages 435–438): John E. DudaChapter 46 Inherited Amyloidoses and Neurodegeneration: Familial British Dementia and Familial Danish Dementia (pages 439–445): Tamas Revesz, Agueda Rostagno, Gordon Plant, Tammaryn Lashley, Blas Frangione, Jorge Ghiso and Janice L. HoltonChapter 47 Neurodegeneration with Brain Iron Accumulation (pages 446–455): John E. Duda and Kurt A. JellingerChapter 48 Familial Encephalopathy with Neuroserpin Inclusion Bodies (pages 456–460): Richard L. Davis and George H. CollinsChapter 49 Hereditary Ferritinopathies (pages 461–466): Ruben Vidal, Marie Bernadette Delisle, Olivier Rascol and Bernardino Ghetti