دانلود کتاب Biotechnology: Bioprocessing, Volume 3, Second Edition

Bioprocessing: an exciting new engineering discipline. It combines the development and optimization of biotechnological processes with effective strategies to recover and purify the desired products. Safety as well as cost play an important role here. This volume covers the immensely differentiated spectrum of techniques and operations of bioprocessing, presented by the most competent experts in the field. An overview of upstream and downstream processing is given, fermentation and cell culture processes and the design of microbial fermenters are presented. A closing group of chapters is dedicated to issues of process validation, measurement, and regulation. Topics included are: Industrial Cell Cultures/ Pharmaceutical Proteins/ Bioreactors/ Media and Air Sterilization/ Oxygen Transfer/ Scale Implications/ Fermentation Data Analysis/ Cell and Debris Removal/ Protein Purification/ Electrokinetic Separations/ Final Recovery Steps/ Process ValidationContent: Chapter 1 Fermentation: An Overview (pages 7–22): Barry C. Buckland and Malcolm D. LillyChapter 2 Industrial Animal Cell Culture (pages 23–38): Brian D. Kelley, Tzyy?Wen Chiou, Morris Rosenberg and Daniel I. C. WangChapter 3 Overview of Downstream Processing (pages 39–55): Ron SpearsChapter 4 Proteins and Peptides as Drugs: Sources and Methods of Purification (pages 57–73): Stuart E. Builder, Robert L. Garnick, James C. Hodgdon and John R. OgezChapter 5 Bioreactors: Description and Modelling (pages 77–104): Jens Nielsen and John VilladsenChapter 6 Cell Culture Bioreactors (pages 105–126): Athanassios Sambanis and Wei?Shou HuChapter 7 Media for Microbial Fermentations (pages 127–139): Randolph L. GreashamChapter 8 Media for Cell Culture (pages 141–156): R. A. WoveChapter 9 Media and Air Sterilization (pages 157–184): Gokaraju K. Raju and Charles L. CooneyChapter 10 Oxygen Transfer and Mixing: Scale?Up Implications (pages 185–217): Matthias ReussChapter 11 Aeration in Cell Culture Bioreactors (pages 219–281): John G. Aunins and Hans?Jurgen HenzlerChapter 12 Strategies for Fermentation with Recombinant Organisms (pages 283–294): Tadayuki ImanakaChapter 13 Anaerobic Fermentations (pages 295–318): Larry E. Erickson, Daniel Y. C. Fung and Pravate TuitemwongChapter 14 Fermentation Monitoring and Control (pages 319–354): Thomas Chattaway, Gary A. Montague and A. Julian MorrisChapter 15 Fermentation Data Analysis for Diagnosis and Control (pages 355–400): Gregory Stephanopoulos, Konstantin Konstantinov, Urs Saner and Toshiomi YoshidaChapter 16 Design of Aseptic, Aerated Fermentors (pages 401–426): Marvin Charles and Jack WilsonChapter 17 Biotransformations and Enzyme Reactors (pages 427–466): Andreas S. BommariusChapter 18 Cell and Cell Debris Removal: Centrif Ugation and Crossflow Filtration (pages 469–503): Rajiv V. Datar and Carl?Gustaf RosenChapter 19 Cell Disruption and Isolation of Non?Secreted Products (pages 505–526): Horst Schutte and Maria?Regina KulaChapter 20 In vitro Protein Refolding (pages 527–555): Jeffrey L. Cleland and Daniel I. C. WangChapter 21 Liquid?Liquid Extraction (Small Molecules) (pages 557–592): Karl SchugerlChapter 22 Protein Purification by Liquid?Liquid Extraction (pages 593–616): Brian D. Kelley and T. Alan HattonChapter 23 Protein Separation and Purification (pages 617–642): Jan?Christer Janson and Lars RydenChapter 24 Affinity Separations (pages 643–677): Srikanth Sundaram and Martin L. YarmushChapter 25 Electrokinetic Separations (pages 679–693): Alan J. Grodzinsky and Martin L. YarmushChapter 26 Final Recovery Steps: Lyophilization, Spray?Drying (pages 695–714): Christian F. GolkerChapter 27 Analytical Protein Chemistry (pages 717–737): Srikanth Sundaram, David M. Yarmush and Martin L. YarmushChapter 28 Biotechnology Facility Design and Process Validation (pages 739–767): Michael G. BeatriceChapter 29 Treatment of Biological Waste (pages 769–787): Daniel F. Liberman