دانلود کتاب Ciba Foundation Symposium - Biosynthesis of Terpenes and Sterols

Volume 1 Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs successfully upholds the goals of the Wiley Encyclopedia of Clinical Trials by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis. Volume 2Featuring newly-written material as well as established literature from the Wiley Encyclopedia of Clinical Trials, this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data. This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored. Content: Chapter 1 Chairman's Opening Remarks (pages 1–3): Sir Robert RobinsonChapter 2 Biogenesis and Transformations of Squalene (pages 4–19): Konrad BlochChapter 3 Discovery and Elucidation of Mevalonic Acid (pages 20–45): Karl Folkers, Clifford H. Shunk, Bruce O. Linn, Franklin M. Robinson, Paul E. Wittreich, Jesse W. Huff, James L. Gilfillan and Helen R. SkeggsChapter 4 Alterations of Cholesterol Biosynthesis in Liver Cell Fractions from Rats in Various Experimental Conditions (pages 46–61): Nancy L. R. BuckerChapter 5 The Enzymic Synthesis of Branched?Chain Acids (pages 62–74): M. J. Coon, F. P. Kupiecki, E. E. Dekker, M. J. Schlesinger and Alice Del CampilloChapter 6 The Biosynthesis of ??Hydroxy???Methyl?Glutaryl Coenzyme a and its Conversion to Mevalonic Acid (pages 75–94): Harry RudneyChapter 7 New Aspects of Acetate Incorporation into Isoprenoid Precursors (pages 95–118): F. Lynen, H. Eggerer, U. Henning, J. Knappe, I. Kessel and E. RingelmannChapter 8 The Mechanism of a Rearrangement Occurring During Biosynthesis of Cholesterol (pages 119–184): J. W. Cornforth, Rita H. Cornforth, Marjorie G. Horning, A. Pelter and G. PopjakChapter 9 Semi?, Mono?, Sesqui?, and Triterpenes as Cholesterol Precursors (pages 135–147): O. Isler, R. Ruegg, G. Saucy, J. Wursch, K. F. Gey and A. PletscherChapter 10 Biosynthesis of Squalene and of Cholesterol from Mevalonic Acid (pages 148–172): G. PopjakChapter 11 Biosynthesis of Yeast Sterols and the Preparation of 14C?Labelled Vitamin D2 (pages 173–184): E. KodicekChapter 12 Bile Acids: Formation and Metabolism (pages 185–205): Sune BergstromChapter 13 Species Comparison as an Aid in the Study of the Process Sterols > Bile Salts (pages 206–216): G. A. D. HaslewoodChapter 14 Some Aspects of Acid?Catalysed Cyclizations of Terpenoid Polyenes (pages 217–230): A. Eschenmoser, Dorothee Felix, M. Gut, J. Meier and P. StadlerChapter 15 Biogenesis of Terpenes in Moulds and Higher Plants (pages 231–244): D. ArigoniChapter 16 The Biosynthesis of Terpenoid Compounds in Fungi (pages 245–266): A. J. Birch and Herchel SmithChapter 17 The Biosynthesis of Carotenoids by Micro?Organisms (pages 267–278): E. C. GrobChapter 18 A Comparison of the Incorporation of Labelled CO2, Acetate and Mevalonate into Carotenoids in a Number of Carotenogenic Systems (pages 279–301): T. W. GoodwinChapter 19 Chairman's Closing Remarks (page 302):