دانلود کتاب Analytical Techniques for Clinical Chemistry: Methods and Applications

This book details the role played by analytical chemistry in fostering clinical research. Readers will discover how a broad range of analytical techniques support all phases of clinical research, from early stages to the implementation of practical applications. Moreover, the contributing authors' careful step-by-step guidance enables readers to better understand standardized techniques and steer clear of everyday problems that can arise in the lab. Analytical Techniques for Clinical Chemistry opens with an overview of the legal and regulatory framework governing clinical lab analysis. Next, it details the latest progress in instrumentation and applications in such fields as biomonitoring, diagnostics, food quality, biomarkers, pharmaceuticals, and forensics. Comprised of twenty-five chapters divided into three sections exploring Fundamentals, Selected Applications, and Future Trends, the book covers such critical topics as: Uncertainty in clinical chemistry measurementsMetal toxicology in clinical, forensic, and chemical pathology Role of analytical chemistry in the safety of drug therapy Atomic spectrometric techniques for the analysis of clinical samples Biosensors for drug analysisUse of X-ray techniques in medical researchEach chapter is written by one or more leading pioneers and experts in analytical chemistry. Contributions are based on a thorough review and analysis of the current literature as well as the authors' own firsthand experiences in the lab. References at the end of each chapter serve as a gateway to the literature, enabling readers to explore individual topics in greater depth. Presenting the latest achievements and challenges in the field, Analytical Techniques for Clinical Chemistry sets the foundation for future advances in laboratory research techniques. Content: Chapter 1 Good Clinical Practice Principles: Legal Background and Applicability (pages 1–27): Umberto Filibeck, Angela Del Vecchio and Fabrizio GallicciaChapter 2 Clinical Chemistry and the Quest for Quality (pages 29–58): Sergio CaroliChapter 3 Uncertainty in Clinical Chemistry Measurements Including Preanalytical Variables (pages 59–96): Marit Sverresdotter Sylte, Tore Wentzel?Larsen and Bjorn J. BolannChapter 4 The Role and Significance of Reference Values in the Identification and Evaluation of Trace Elements from Diet (pages 97–125): Pietro Apostoli and Maria Cristina RicossaChapter 5 Sample Collection, Storage, and Pretreatment in Clinical Chemistry (pages 127–137): Andrew TaylorChapter 6 Metal Toxicology in Clinical, Forensic, and Chemical Pathology (pages 139–156): Jose A. Centeno, Todor I. Todorov, Gijsbert B. van der Voet and Florabel G. MullickChapter 7 Elemental Speciation in Clinical Sciences (pages 157–177): Douglas M. TempletonChapter 8 The Role of Analytical Chemistry in the Safety of Drug Therapy (pages 179–243): Sandor GorogChapter 9 Analytical Techniques and Quality Control of Pharmaceuticals (pages 245–255): Fedele Manna, Francesca Rossi and Rossella FioravantiChapter 10 Detection of Drugs in Biological Fluids for Antidoping Control (pages 257–268): Sabina Strano and Marcello ChiarottiChapter 11 The Applicability of Plasma?Based Techniques to Biological Monitoring (pages 269–317): Ilse Steffan and Goran VujicicChapter 12 Atomic Spectrometric Techniques for the Analysis of Clinical Samples (pages 319–366): Pilar Bermejo Barrera, Antonio Moreda Pineiro and Maria del Carmen Barciela AlonsoChapter 13 Applications of ICP?MS in Human Biomonitoring Studies (pages 367–395): Peter Heitland and Helmut D. KosterChapter 14 Molybdenum in Biological Samples and Clinical Significance of Serum Molybdenum (pages 397–408): Munehiro YoshidaChapter 15 Application of Organometallic Speciation in Clinical Studies (pages 409–453): Bin He, Chungang Yuan, Jing Sun and Guibin JiangChapter 16 Biosensors for Drug Analysis (pages 455–478): Daniela Deriu and Franco MazzeiChapter 17 Bioimaging of Metals and Proteomic Studies of Clinical Samples by Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA?ICP?MS) (pages 479–505): Sabine Becker and Susanne BeckerChapter 18 Applications of LC?MS/MS in Clinical Laboratory Diagnostics (pages 507–534): Uta Ceglarek, Georg Martin Fiedler and Joachim ThieryChapter 19 Metabolomics Using UPLC/HPLC?Tandem Mass Spectrometry in Diagnosis and Research of Inherited Metabolic Diseases (pages 535–553): Willem Kulik and Andre B. P. van KuilenburgChapter 20 Biomarkers of Oxidative Stress in Plasma and Urine (pages 555–594): Papasani V. SubbaiahChapter 21 The Use of X?Ray Techniques in Medical Research (pages 595–623): Imre Szaloki, Gyula Zaray and Norbert SzoboszlaiChapter 22 A New Tool Based on the Use of Stable Isotopes and Isotope Pattern Deconvolution (IPD)?ICP?MS for Nutritional and Clinical Studies (pages 625–649): Hector Gonzalez Iglesias, Maria Luisa Fernandez?Sanchez and Alfredo Sanz?MedelChapter 23 Breath Analysis: Analytical Methodologies and Clinical Applications (pages 651–689): Alessio Ceccarini, Fabio Di Francesco, Roger Fuoco, Silvia Ghimenti, Massimo Onor, Sara Tabucchi and Maria Giovanna TrivellaChapter 24 Proteo?Metabolomic Strategies in the Future of Drug Development (pages 691–774): Uwe Christians, Volker Schmitz, Jost Klawitter and Jelena KlawitterChapter 25 Basics in Laboratory Medicine: Past, Present, and Future (pages 775–785): Lorand A. Debreczeni, Anna Kovacsay and Sandor Nagy