جزییات کتاب
Volume 1 Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs successfully upholds the goals of the Wiley Encyclopedia of Clinical Trials by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis. Volume 2Featuring newly-written material as well as established literature from the Wiley Encyclopedia of Clinical Trials, this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data. This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored. Content: Chapter 1 Chairman's Opening Remarks (pages 1–2): S. ZuckermanChapter 2 Sex and Species Differences in the Behavioural Effects of Gonadal Hormones (pages 3–17): Frank A. BeachChapter 3 Sex Differences in the Maturation and Function of the Nervous System in the Rat (pages 18–33): J. T. EayrsChapter 4 The Influence of Sex Hormones on the Performance of a Learned Response (pages 34–46): S. ZuckermanChapter 5 Patterns of Male Sex Behaviour (pages 47–54): Arthur WaltonChapter 6 The Experimental Induction of Sexual Behaviour by Steroid Hormones (pages 55–60): Edward W. DempseyChapter 7 On the Excretion of Neutral Steroids in the Urine of Normaland Infertile Bulls (pages 61–73): P. MeschaksChapter 8 Observations on Reproduction Behaviour in Zoo Animals (pages 74–83): H. HedigerChapter 9 Uterine Distension, Ovarian Hormones and Maternal Behaviour in Rodents (pages 84–88): Marc KleinChapter 10 The Effect of Domestication on the Steroids of Animals and Man (pages 89–111): Curt P. RichterChapter 11 The Interplay Between Endocrine Disturbances and Psychological Aberrations (pages 112–119): J. S. L. BrowneChapter 12 Behaviour Patterns and Psychiatric Disturbances in Major Endocrine Disorders (pages 120–127): S. Leonard SimpsonChapter 13 Psychological Changes Connected with Spontaneous and Experimentally Produced Alterations in Steroid Hormone Metabolism (pages 128–140): Max ReissChapter 14 Observations on the Mechanism of the Disordered Psychological Outlook in Addison's Disease and Hypopituitarism (pages 141–153): R. A. CleghornChapter 15 Adrenal Function in Schizophrenic Men (pages 154–167): Gregory PincusChapter 16 Clinical Types of Altered Sexuality in Relation to Adrenalectomy (pages 168–174): L. R. BrosterChapter 17 The Relationship of Steroids to Psychosis (pages 175–186): Clifford AllenChapter 18 Alterations in Psychological States by Therapeutic Increase in Adrenal Cortical Hormones (pages 187–196): R. A. CleghornChapter 19 Effects of Acth and Cortisone on Behaviour (pages 197–208): J. S. L. BrowneChapter 20 Mechanisms of Hormonal Action Upon Behaviour (pages 209–220): Frank A. BeachChapter 21 Chairman's Closing Remarks (pages 239–246): S. Zuckerman