دانلود کتاب Ciba Foundation Symposium - Lysosomes

Volume 1 Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs successfully upholds the goals of the Wiley Encyclopedia of Clinical Trials by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis. Volume 2Featuring newly-written material as well as established literature from the Wiley Encyclopedia of Clinical Trials, this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data. This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored. Content: Chapter 1 The Lysosome Concept (pages 1–35): Christian de DuveChapter 2 Lysosomes in the Physiology and Pathology of Cells: Contributions of Staining Methods (pages 36–77): Alex B. NovikoffChapter 3 Lysosomes: Distribution in Animals, Hydrolytic Capacity and Other Properties (pages 78–113): A. L. Tappel, P. L. Sawant and S. ShibkoChapter 4 Some Observations on the Occurrence and Nature of Esterases in Lysosomes (pages 114–125): S. J. HoltChapter 5 The Cytoplasmic Granules of Phagocytic Cells and the Degradation of Bacteria (pages 126–150): Zanvil A. Cohn, James G. Hirsch and Edith WienerChapter 6 Dynamics of Adrenal Function in Man (pages 151–175): Peter H. Forsham, Vincent Di Raimondo, Donald Island, Arthur P. Rinfret and Richard H. OrrChapter 7 Influence of the Injection of Triton Wr?1339 On the Properties of Rat?Liver Lysosomes (pages 176–200): R. Wattiaux, M. Wibo and P. BaudhuinChapter 8 Fine Structure and Enzymic Activity of Protozoan Food Vacuoles (pages 201–225): M. Muller, P. Rohlich, J. Toth and I. ToroChapter 9 The Relation to Lysosomes of the In Vivo Metachromatic Granules (pages 226–263): A. M. DalcqChapter 10 Properties and Role of Acid Hydrolases of the Mullerian Ducts During Sexual Differentiation in the Male Chick Embryo (pages 264–281): Denise ScheibChapter 11 Behaviour and Properties of Acid Hydrolases in Regressing Tails of Tadpoles During Spontaneous and Induced Metamorphosis In Vitro (pages 282–310): Rudolf WeberChapter 12 Lysosomal Changes During Liver Injury and Mammary Involution (pages 311–335): T. F. Slater, A. L. Greenbaum and D. Y. WangChapter 13 Lysosome Changes in Liver Injury (pages 335–361): Mario Umberto DianzaniChapter 14 The Reversible Activation of Lysosomes in Normal Cells and the Effects of Pathological Conditions (pages 362–383): Lucille BitenskyChapter 15 Action of Vitamin A on the Stability of Lysosomes In Vivo and In Vitro (pages 384–404): J. T. Dingle