جزییات کتاب
Volume 1 Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs successfully upholds the goals of the Wiley Encyclopedia of Clinical Trials by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis. Volume 2Featuring newly-written material as well as established literature from the Wiley Encyclopedia of Clinical Trials, this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data. This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored. Content: Chapter 1 Chairman's Opening Remarks (pages 1–2): O. G EdholmChapter 2 A Critical Survey of Methods Available for the Measurement of Human Peripheral Blood Flow (pages 3–22): Alan C. BurtonChapter 3 A Method for Recording and a Study of the Venous Occlusive Technique for Measuring the Time Course of the Rate of Inflow and the Time Course of the Rate of Outflow in the Finger Tip of Man During a Single Pulse Cycle (pages 23–44): G. E. BurchChapter 4 The Electrical Strain Gauge Method for Measurement of Peripheral Circulation in Man (pages 45–57): R. J. WhitneyChapter 5 The Transparent Chamber Technique for Observation of the Peripheral Circulation, as Studied in Mice (pages 58–67): Glenn H. AlgireChapter 6 Differentzal Secretion of Adrenaline and Noradrenaline from the Suprarenal Gland (pages 68–74): U. S. van EulerChapter 7 The Effect of Adrenaline and Noradrenaline on the Blood Flow Through Human Skeletal Muscle (pages 75–91): R. F. WhelanChapter 8 Changes in Peripheral Circulation with Exposure to Cold (pages 92–104): Loren D. CarlsonChapter 9 The Response to Cold in the Range 0–10°C. (pages 105–114): A. D. M. GreenfieldChapter 10 Factors Concerned in the Regulation of Skin Blood Flow (pages 115–121): D. McK. Kerslake and K. E. CooperChapter 11 Blood Flow Response to Temperature and Other Factors (pages 122–131): H. Barcroft and A. C. DornhorstChapter 12 Observations on the Neurohistology of Cutaneous Blood Vessels (pages 132–142): G. Weddell and W. PallieChapter 13 Some Aspects of the Reflex Control of the Cutaneous Circulation (pages 143–152): K. E. Cooper and D. McK. KerslakeChapter 14 The Problem of Vasomotor Denervation (pages 153–166): A. B. Hertzman, W. C. Randall, J. W. Cox, W. F. Alexander and K. B. ColdwaterChapter 15 Vascular Reactivity Following Sympathectomy (pages 167–172): R. T. GrantChapter 16 Some Anatomical Observations on Peripheral Ischbmia in Man (pages 173–184): J. Henry DibleChapter 17 The Mechanism of the Raynaud's Phenomenon in Patients with High Serum Titres of Cold Agglutinins (pages 185–191): J. T. ShepherdChapter 18 Visceral Activity and Peripheral Circulation in the Spinal Man (pages 192–203): L. GuttmannChapter 19 Some Aspects of Functional Disorders of the Circulation (pages 204–210): P. Martin