جزییات کتاب
Volume 1 Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs successfully upholds the goals of the Wiley Encyclopedia of Clinical Trials by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis. Volume 2Featuring newly-written material as well as established literature from the Wiley Encyclopedia of Clinical Trials, this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data. This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored. Content: Chapter 1 Relation Between Effect and Method of Administration of Androgens and Estrogens to Fowl (pages 248–253): A. S. ParkesChapter 2 Some Data on Emulsions of Steroid Hormones (pages 254–262): C. A. OverbeekChapter 3 Data on Relative Absorption Rates of Subcutaneous Pellets of Steroid —Hormones in Rats (pages 263–264): T. R. ForbesChapter 4 Studies on the Absorption of Pellets of Steroid Hormones and Related Substances in Man (pages 265–282): P. M. F. Bishop and S. J. FolleyChapter 5 Absorption Data from Tablet Implantation Experiments in Ruminants (pages 283–290): F. H. MalpressChapter 6 Data on Progesterone Physiology and Metabolism (pages 291–303): T. R. ForbeswChapter 7 17?Ketosteroid Excretion and Modes of Administering Testosterone Preparations (pages 304–322): Christian HamburgerChapter 8 Administration of Sex Hormones and Sexual Behaviour (pages 323–337): M. KleinChapter 9 Artificial Induction of Lactation in Goats by Steroid Hormones and Synthetic Estrogens (pages 338–348): A. T. CowieChapter 10 The Difficulty of Evaluating the Potency of Steroid Hormones by Different Routes of Administration in Humans (pages 349–355): P. M. F. BishopChapter 11 Observations on the Results of Pharmacological Assay of Synthetic Estrogens and Their Clinical Effects (pages 356–360): W. A. BroomChapter 12 Clinical Impressions of Values of ?strogens and Androgens Administered by Different Routes (pages 361–369): G. L. FossChapter 13 Chairman's Closing Remarks (pages 370–374): J. H. Gaddum