جزییات کتاب
Volume 1 Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs successfully upholds the goals of the Wiley Encyclopedia of Clinical Trials by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis. Volume 2Featuring newly-written material as well as established literature from the Wiley Encyclopedia of Clinical Trials, this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data. This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored. Content: Chapter 1 Aspects of the Histochemistry of the Adrenal Cortex (pages 1–17): G. H. BourneChapter 2 Some Observations on the Problem of Cortical Zoning (pages 18–30): J. M. YoffeyChapter 3 Mitotic Activity in the Adrenal Cortex Studied in the Rat (pages 31–41): D. B. Cater and M. P. Stack?DunneChapter 4 Cellular?Vascular Relationships in the Adrenal Cortex, as Studied in the Rat (pages 42–51): J. D. LeverChapter 5 Studies on the Anatomy of the Human Adrenal Cortex in Various Functional States (pages 52–69): Benjamin H. LandingChapter 6 The Reaction of the Adrenal Cortex in Conditions of Stress (pages 70–91): T. Symington, A. R. Currie, R. C. Curran and J. N. DavidsonChapter 7 The Adrenal and Famine (pages 92–96): E. UehlingerChapter 8 The Synthesis of Corticosteroids by the Human Adrenal Cortexs (pages 97–111): G. Pincus and E. B. RomanoffChapter 9 Adrenocortical Steroids in Humans: Metabolism and Generalizations (pages 112–140): Ralph I. DorfmanChapter 10 Adrenocortical Function and Plasma 17?Ketosteroids in Man (pages 141–156): Claude MigeonChapter 11 Gradient Elution Chromatography of Corticosteroids in Human Blood (pages 157–169): C. J. O. R. Morris and D. C. WilliamsChapter 12 The Biosynthesis of Aldosterone (Electrocortin) in the Adrenal (pages 170–189): A. Wettstein, F. W. Kahnt and R. NeherChapter 13 Excretion of Sodium?Retaining Substances in Human Beings (pages 190–203): E. H. Venning, Bertha Singer, A. Carballeira, I. Dyrenfurth, J. C. Beck and C. P. GiroudChapter 14 The Possible Role of Electrocortin in Normal Human Metabolism (pages 204–227): Sylvia A. Simpson and J. F. TaitChapter 15 Biological Studies with Aldosterone (Electrocortin) (pages 228–240): Robert GauntChapter 16 Medullary?Cortical Relationships in the Adrenal (pages 241–253): Marthe VogtChapter 17 The Effect of Epinephrine on the Metabolism of 17?Hydroxycorticosteroids in the Human (pages 254–267): F. H. Tyler, C. Migeon and H. CastleChapter 18 Relationship Between Cortical Hormones and the Catechol Amine Output in Urine (pages 268–276): U. S. von Euler