جزییات کتاب
Volume 1 Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs successfully upholds the goals of the Wiley Encyclopedia of Clinical Trials by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis. Volume 2Featuring newly-written material as well as established literature from the Wiley Encyclopedia of Clinical Trials, this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data. This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored. Content: Chapter 1 The Structural and Functional Aspects of Recovery from Acute Renal Failure (pages 1–14): Jean OliverChapter 2 Preliminary Experiences with Aspiration Biopsy of the Kidney (pages 15–26): Flemming RaaschouChapter 3 Renal Lesions in Relation to Amino?Aciduria and Water Diuresis (pages 27–37): E. M. DarmadyChapter 4 The Production of Hypertonic Urine by the Mammalian Kidney (pages 38–49): H. WirzChapter 5 Distribution of Functional Activity Among the Nephron Population (pages 50–64): S. E. Bradley, E. Leifer and J. F. NickelChapter 6 Some Biochemical Features of Tubular Transport Mechanisms (pages 65–78): John V. TaggartChapter 7 A Study of the Mechanism by which Toxic Tubular Damage Changes the Renal Threshold for Glucose (pages 79–95): P. P. LambertChapter 8 Glucose Titration in Renal Glycosuria (pages 96–113): F. C. ReubiChapter 9 Renal Acid?Base Control and Cell Physiology (pages 114–124): J. R. RobinsonChapter 10 Regulation of the Content of Bicarbonate Bound Base in Body Fluids (pages 125–146): Robert F. Pitts, W. James Sullivan and Philip J. DormanChapter 11 The Relationship Between Potassium Excretion and Urine Acidification (pages 147–164): Robert W. Berliner, Thomas J. Kennedy and Jack OrloffChapter 12 Renal Response to Massive Alkali Loading in the Human Subject (pages 165–176): P. H. SandersonChapter 13 Mechanisms of Sodium Retention (pages 177–192): John P. MerrillChapter 14 Post?Operative Retention of Water and Sodium (pages 193–211): L. P. Le Quesne and A. A. G. LewisChapter 15 Electrolyte Excretion in States of Potassium Depletion in Man (pages 212–223): M. D. Milne, N. C. Hughes Jones and B. M. EvansChapter 16 Treatment of Electrolyte?Fluid Retention by Ultrafiltration of the Blood in vivo (pages 224–241): Nils AlwallChapter 17 Some Aspects of Calcium and Phosphorus Excretion (pages 242–254): C. E. DentChapter 18 The Characteristic Renal Excretion Patterns Associated with Excessive or Inadequate Circulation (pages 255–287): J. G. G. BorstChapter 19 Fluid Balance in Anuria (pages 288–308): Jean Hamburger and Georges MatheChapter 20 Renal Factors in Volume Control (pages 309–322): D. A. K. Black