جزییات کتاب
Volume 1 Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs successfully upholds the goals of the Wiley Encyclopedia of Clinical Trials by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis. Volume 2Featuring newly-written material as well as established literature from the Wiley Encyclopedia of Clinical Trials, this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data. This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored. Content: Chapter 1 Virus Structure: General Principles (pages 5–18): F. H. C. Crick and J. D. WatsonChapter 2 Structure and Substructure of Viruses as Seen Under the Electron Microscope (pages 19–38): Robley C. WilliamsChapter 3 X?Ray Diffraction Studies of the Structure and Morphology of Tobacco Mosaic Virus (pages 39–55): Rosalind E. Franklin, A. Klug and K. C. HolmesChapter 4 Material in Virus Preparations not Necessary for the Manifestation of Characteristic Virus Properties (pages 56–68): N. W. PirieChapter 5 Some Recent Developments in the Chemistry of Virus Mutants (pages 69–90): C. A. KnightChapter 6 Units Isolated After Splitting Fowl Plague Virus (pages 91–103): Werner SchaferChapter 7 Ribonucleic Acid in Influenza Virus (pages 104–122): G. L. AdaChapter 8 Chemical Inactivation of Viruses (pages 123–146): Sven GardChapter 9 Quantitative Aspects of Virus Growth in Cultivated Animal Cells (pages 147–157): R. DulbeccoChapter 10 The Multiplication of Animal Viruses (pages 158–169): F. K. SandersChapter 11 The Multiplication of Plant Viruses (pages 170–190): F. C. BawdenChapter 12 Studies on Mixed Infections with Influenza Viruses (pages 191–202): George K. Hirst, Tamar Gotlieb and Allan GranoffChapter 13 The Morphological Aspects of Virus Infections of Cells as Revealed by Fluorescent Antibody (pages 203–210): Albert H. CoonsChapter 14 The Use of Radioactive Influenza Virus to Determine the Fate of the Infecting Particle on Entry into the Host Cell (pages 211–223): L. HoyleChapter 15 The Size Distribution of Specific Antigens in Virus?Infected Tissues and their Significance (pages 224–248): A. Kipps, W. du T. Naude, A. Polson, G. Selzer and M. Van Den EndeChapter 16 Morphological Aspects of Virus Cell Relationships in Influenza, Mumps and Newcastle (Myzovirus) (pages 249–262): F. B. Bang and A. IsaacsChapter 17 Interaction of Phages with Bacterial Cell Walls and the Development of Phage in the Wall?Less Protoplast (pages 263–276): M. R. J. SaltonChapter 17a General Discussion (pages 276–286):