دانلود کتاب Ciba Foundation Symposium - The Pineal Gland

Volume 1 Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs successfully upholds the goals of the Wiley Encyclopedia of Clinical Trials by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis. Volume 2Featuring newly-written material as well as established literature from the Wiley Encyclopedia of Clinical Trials, this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data. This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored. Content: Chapter 1 Chairman's Introduction (pages 1–2): Professor L. MartiniChapter 2 The Pineal Organ: An Introduction (pages 3–34): J. Ariens KappersChapter 3 Neural Control of Indoleamine Metabolism in the Pineal (pages 35–52): Julius AxelrodChapter 4 Developmental Aspects of Amphibian Pineal Systems (pages 53–77): Douglas E. KellyChapter 5 Differentiation and Regression of the Cells of the Sensory Line in the Epiphysis Cerebri (pages 79–125): Jean?Pierre CollinChapter 6 Sensory and Glandular Elements of the Pineal Organ (pages 127–146): A. OkscheChapter 7 Secretory Organelles of the Rat Pineal Gland: Electron Microscopic and Histochemical Studies in vivo and in vitro (pages 147–175): Antti U. Arstila, Hannu O. Kalimo and Markku HyyppaChapter 8 Two Compartments in the Granulated Vesicles of the Pineal Nerves (pages 177–195): Amanda Pellegrino de Iraldi and Angela Maria SuburoChapter 9 Control of Melatonin Synthesis by Noradrenaline in Rat Pineal Organ Cultures (pages 197–212): Harvey M. SheinChapter 10 Pineal?Brain Relationships (pages 213–227): Fernando Anton?TayChapter 11 Luteinization Induced by Pinealectomy in the Polyfollicular Ovaries of Rats Bearing Anterior Hypothalamic Lesions (pages 229–240): B. Mess, A. Heizer, A. Toth and L. TimaChapter 12 Biochemical Fractions and Mechanisms Involved in the Pineal Modulation of Pituitary Gonadotropin Release (pages 241–258): A. Moszkowska, C. Kordon and I. EbelsChapter 13 Mechanisms of Inhibitory Action of Pineal Principles on Gonadotropin Secretion (pages 259–278): F. Fraschini, R. Collu and L. MartiniChapter 14 Pineal Principles and the Control of Adrenocorticotropin Secretion (pages 279–301): Marceixa Motta, O. Schiaffini, F. Piva and L. MartiniChapter 15 The Role of the Pineal Gland in the Control by Light of the Reproductive Cycle of the Ferret (pages 303–327): J. HerbertChapter 16 Factors Influential in Determining the Gonad?Inhibiting Activity of the Pineal Gland (pages 329–344): Russel J. Reiter and Sandy SorrentinoChapter 17 The Effect of Pinealectomy on Plasma Insulin in Rats (pages 345–360): Stefan M. Milcu, Lydia Nanu?Ionescu and Ioana MilcuChapter 18 General Discussion: Role of Serotonin in the Pineal (pages 361–377): Chapter 19 Summary of Symposium (pages 379–389): R. J. Wurtman