دانلود کتاب Ciba Foundation Symposium - Touch, Heat and Pain

Volume 1 Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs successfully upholds the goals of the Wiley Encyclopedia of Clinical Trials by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis. Volume 2Featuring newly-written material as well as established literature from the Wiley Encyclopedia of Clinical Trials, this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data. This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored. Content: Chapter 1 Chairman's Introduction (pages 1–2): Professor O. E. LowensteinChapter 2 Transfer Functions of the Skin and Muscle Senses (pages 3–26): S. S. StevensChapter 3 Tissue Temperature and Thermal Pain (pages 27–56): J. D. Hardy and J. A. J. StolwijkChapter 4 Measurement of Responses to Chemically Induced Pain (pages 57–79): C. A. KeeleChapter 5 General Discussion of Section I (pages 80–85): Chapter 6 Unit Design and Array Patterns in Receptor Organs (pages 86–116): T. A. QuilliamChapter 7 Fine Structure of the Receptor Organs and its Probable Functional Significance (pages 117–136): Nikolajs CaunaChapter 8 General Discussion of Section II (pages 137–144): Chapter 9 The Relationship of Skin Displacement to Receptor Activation (pages 145–163): U. LindblomChapter 10 Nerve Membrane Properties and Thermal Stimuli (pages 164–185): Richard W. MurrayChapter 11 Input and Output Ends of a Transducer Process (pages 186–202): Werner R. LoewensteinChapter 12 Initiation of Impulses by Mechanosensory Nerve Terminals (pages 203–231): M. Sato and M. OzekiChapter 13 General Discussion of Section III (pages 232–236): Chapter 14 Cutaneous Receptors with a High Sensitivity to Mechanical Displacement (pages 237–260): A. IggoChapter 15 Excitation of the Dentinal Receptor in the Tooth of the Cat (pages 261–274): Donald ScottChapter 16 Classes of Receptor Units Predominantly Related to Thermal Stimuli (pages 275–290): Herbert HenselChapter 17 General Discussion of Section IV (pages 291–298): Chapter 18 The Representation of Information of Receptor Units Signalling Mechanical Events About Rapid Changes in a Population (pages 299–324): J. A. B. GrayChapter 19 The Neural Transformation of Mechanical Stimuli Delivered to the Monkey's Hand (pages 325–351): Vernon B. Mountcastle, William H. Talbot and Hans H. KornhuberChapter 20 General Discussion of Section V (pages 352–358): Chapter 21 Concluding Discussion (pages 359–374): Chapter 22 Chairman's Closing Remarks (pages 375–376): Professor O. E. Lowenstein