دانلود کتاب Ciba Foundation Symposium - Congenital Malformations

Volume 1 Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs successfully upholds the goals of the Wiley Encyclopedia of Clinical Trials by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis. Volume 2Featuring newly-written material as well as established literature from the Wiley Encyclopedia of Clinical Trials, this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data. This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored. Content: Chapter 1 Malformations in a Population Observed for Five Years After Birth (pages 2–21): Thomas McKeown and R. G. RecordChapter 2 Genetical Causes of Malformation and the Search for Their Origins (pages 22–31): L. S. PenroseChapter 3 Chromosomal Abnormality and Congenital Malformation (pages 32–50): C. E. FordChapter 4 Environmental Factors in Causation of Congenital Anomalies (pages 51–77): T. H. IngallsChapter 5 Teratogenig Effects of Tumour?Inhibiting Chemicals in the Foetal Rat (pages 78–114): M. Lois MurphyChapter 6 The Teratogenic Action of the Antibiotic Actinomycin D (pages 115–133): H. Tuchmann?Duplessis and L. Mercier?ParotChapter 7 Teratogenig Effects of Pteroylglutamic Acid Deficiency in the Rat (pages 134–157): Marjorie M. NelsonChapter 8 The Modification of the Activity of Certain Agents Exerting a Deleterious Effect on the Development of the Mammalian Embryo (pages 158–177): D. H. M. Woollam and J. W. MillenChapter 9 Congenital Runts (pages 178–198): Anne McLaren and Donald MichieChapter 10 Causes and Morphogenesis of Anencephaly (pages 199–218): A. GiroudChapter 11 Causes of Congenital Malformations: Role of Prediabetes and Hypothyroidism (pages 219–240): J. P. Hoet, Adrienne Gommers and J. J. HoetChapter 12 The Association of Hydramnios with Congenital Malformations (pages 241–267): A. C. StevensonChapter 12a General Discussion (pages 268–292):