دانلود کتاب Modern Tools for the Synthesis of Complex Bioactive Molecules

All the latest tools needed to plan and perform the synthesis of complex bioactive moleculesFocusing on organic, organometallic, and bio-oriented processes, this book explores the impact and use of the latest synthetic tools for the synthesis of complex biologically active compounds. Readers will discover step by step how these synthetic tools have provided new, elegant solutions to many synthetic puzzles. Moreover, they will discover innovative methods that make it possible to control the exact connectivity of atoms within a molecule in order to set precise three-dimensional arrangements. Modern Tools for the Synthesis of Complex Bioactive Molecules features sixteen chapters, each one written by one or more leading experts in organic synthesis from around the world. It covers a broad range of topics that enable readers to take advantage of the latest methods for synthesizing complex molecules, including: Modern catalysis, emphasizing key transformations such as C-H functionalizations, cross-couplings, gold-catalyzed reactions, metathesis-based syntheses, and asymmetric organocatalysisEco-compatible transformations, including rearrangements and domino reactionsTools for the synthesis of carbohydrates and alkaloidsNew techniques, including the use of fluorous tags and engineered biosynthesisThe last two chapters explore target- and diversity-oriented organic synthesis as well as the use of DNA-based asymmetric catalysis, which are all promising tools for the successful synthesis of complex bioactive molecules. Modern Tools for the Synthesis of Complex Bioactive Molecules is ideal for students and researchers who need to plan and perform the synthesis of complex molecules as efficiently as possible. The book's expert advice will help these readers quickly resolve a broad range of problems that can arise in organic syntheses.Content: Chapter 1 C–H Functionalization: A New Strategy for the Synthesis of Biologically Active Natural Products (pages 1–32): Sophie Rousseaux, Benoit Liegault and Keith FagnouChapter 2 The Negishi Cross?Coupling in the Synthesis of Natural Products and Bioactive Molecules (pages 33–75): Evelina Colacino, Jean Martinez and Frederic LamatyChapter 3 Metal?Catalyzed C–Heteroatom Cross?Coupling Reactions (pages 77–109): Renata Marcia de Figueiredo, Jean Marc Campagne and Damien PrimChapter 4 Golden Opportunities in the Synthesis of Natural Products and Biologically Active Compounds (pages 111–154): Fabien GagoszChapter 5 Metathesis?Based Synthesis of Complex Bioactives (pages 155–188): Jean?Alexandre Richard, Sin Yee Ng and David Y.?k. ChenChapter 6 Enantioselective Organocatalysis: A Powerful Tool for the Synthesis of Bioactive Molecules (pages 189–212): Mitsuru Shoji and Yujiro HayashiChapter 7 Asymmetric Phase?Transfer Catalysis (pages 213–242): Seiji Shirakawa, Shin A. Moteki and Keiji MaruokaChapter 8 Rearrangements in Natural Product Synthesis (pages 243–269): Jose Marco?Contelles and Elena SorianoChapter 9 Domino Reactions in the Enantioselective Synthesis of Bioactive Natural Products (pages 271–334): Lutz F. Tietze, Scott G. Stewart and Alexander DufertChapter 10 Fluorous Linker?Facilitated Synthesis of Biologically Interesting Molecules (pages 335–357): Wei ZhangChapter 11 The Evolution of Immobilized Reagents and their Application in Flow Chemistry for the Synthesis of Natural Products and Pharmaceutical Compounds (pages 359–393): Rebecca M. Myers, Kimberley A. Roper, Ian R. Baxendale and Steven V. LeyChapter 12 Synthetic Approaches to Bioactive Carbohydrates (pages 395–432): Xavier Guinchard, Sebastien Picard and David CrichChapter 13 Ammonium Ylides as Building Blocks for Alkaloid Synthesis (pages 433–484): Scott Bur and Albert PadwaChapter 14 Precursor?Directed Biosynthesis of Polyketide and Nonribosomal Peptide Natural Products (pages 485–512): Colin J. B. Harvey and Chaitan KhoslaChapter 15 Target?Oriented and Diversity?Oriented Organic Synthesis (pages 513–518): Raphael RodriguezChapter 16 DNA as a Tool for Molecular Discovery (pages 539–555): Michael Smietana, Jean?Jacques Vasseur, Janine Cossy and Stellios Arseniyadis