دانلود کتاب Ciba Foundation Symposium 76 - Environmental Chemicals, Enzyme Function and Human Disease

Content: Chapter 1 Chairman's Introduction (pages 1–2): Chapter 2 The Role of the Drug?Metabolizing Enzymes (pages 5–24): James W. BridgesChapter 3 The Influence of Inducers on Drug?Metabolizing Enzyme Activity and on Formation of Reactive Drug Metabolites in the Liver (pages 25–42): Sten Orrenius, Hjordis Thor and Bengt JernstromChapter 4 Effects of Inducers and Inhibitors on Drug?Metabolizing Enzymes and on Drug Toxicity in Extrahepatic Tissues (pages 43–66): Michael R. BoydChapter 5 Induction of Enzymes Involved in DNA Repair and Mutagenesis (pages 67–81): B. A. BridgesChapter 6 Induction of Drug?Metabolizing Enzymes by Polycyclic Aromatic Hydrocarbons: Mechanisms, and some Implications in Environmental Health Research (pages 83–99): John R. BendChapter 7 Induction of Drug?Metabolizing Enzymes by Phenobarbitone: Structural and Biochemical Aspects (pages 101–118): Urs A. Meyer, Peter J. Meier, Hans Hirsiger, Urs Giger and Felix R. AlthausChapter 8 Substrate?Dependent Irreversible Inactivation of Cytochrome P?450: Conversion of Its Haem Moiety into Modified Porphyrins (pages 119–139): Francesco De Matteis, Anthony H. Gibbs, Lavinia Cantoni and Jean FrancisChapter 9 Regulation of Human Drug Metabolism by Dietary Factors (pages 147–167): A.H. Conney, M.K. Buening, E.J. Pantuck, C.B. Pantuck, J.G. Fortner, K.E. Anderson and A. KappasChapter 10 Infiuence of Foreign Compounds on Formation and Disposition of Reactive Metabolites (pages 169–189): F. OeschChapter 11 Pharmacokinetic Factors Governing the Steady?State Concentrations of Foreign Chemicals and Their Metabolites (pages 191–217): James R. GilletteChapter 12 Toxicological Implications of Polymorphic Drug Metabolism (pages 219–244): J.C. Ritchie, T.P. Sloan, J.R. Idle and R.L. SmithChapter 13 Immunologically Mediated Toxicity (pages 245–259): H.E. AmosChapter 14 Toxicological Significance of Liver Hypertrophy Produced by Inducers of Drug?Metabolizing Enzymes (pages 261–274): Emmanuel FarberChapter 15 The Influence of Nutrition and Inducers on Mechanisms of Toxicity in Humans and Animals (pages 275–288): Andre E.M. McLean, David J. Wltts and Denise TameChapter 16 Influence of Environmental Chemicals on Drug Therapy in Humans: Studies with Contraceptive Steroids (pages 289–306): A.M. Breckenridge, D.J. Back, Karen Cross, Francesca Crawford, M. MacIver, M. L'E Orme, P.H. Rowe and Eileen SmithChapter 17 Vitamin D Metabolism in Patients Treated with Phenytoin and Phenobarbitone (pages 315–330): J.O. Hunter and M. DavieChapter 18 Chemical Disease in Humans: Problems in Comparative Toxicology (pages 331–347): Irving J. SelikoffChapter 19 Implications for Future Studies in Humans (pages 349–358): John Higginson