دانلود کتاب New Frontiers in Ultrasensitive Bioanalysis: Advanced Analytical Chemistry Applications in Nanobiotechnology, Single Molecule Detection, and Single Cell Analysis

An overview of current research and developments in ultrasensitive bioanalysis New platforms of ultrasensitive analysis of biomolecules and single living cells using multiplexing, single nanoparticle sensing, nano-fluidics, and single-molecule detection are advancing every scientific discipline at an unprecedented pace. With chapters written by a diverse group of scientists working in the forefront of ultrasensitive bioanalysis, this book provides an overview of the current status and an in-depth understanding of the objectives and future research directions of ultrasensitive bioanalysis. Spanning a wide spectrum of new research approaches, this book: Introduces new theories, ideas, methodologies, technologies, and applications of ultrasensitive bioanalysis in a wide variety of research fields Includes background, fundamentals, and descriptions of instrumentation and techniques behind every experimental design and approach to help readers explore the promising applications of new tools Covers single molecule detection (SMD), single living cell analysis, multi-functional nanoparticle probes, miniaturization, multiplexing, quantitative and qualitative analysis of metal ions and small molecules, and more Discusses techniques such as single molecule microscope and spectroscopy, single nanoparticle optics, single nanoparticle sensors, micro- and nano-fluidics, microarray detection, ultramicroelectrodes, electrochemiluminescence, mass spectrometry, and more This book will be a useful resource and an inspiration for scientists and graduate and undergraduate students in a wide variety of research fields, including chemistry, biology, biomedical science and engineering, and materials science and engineering.Content: Chapter 1 Is One Enough? (pages 1–27): Andrew C. Beveridge, James H. Jett and Richard A. KellerChapter 2 Dissecting Cellular Activity from Single Genes to Single mRNAs (pages 29–39): Xavier Darzacq, Robert H. Singer and Yaron Shav?TalChapter 3 Probing Membrane Transport of Single Live Cells Using Single?Molecule Detection and Single Nanoparticle Assay (pages 41–70): Xiao?Hong Nancy Xu, Yujun Song and Prakash NallathambyChapter 4 Nanoparticle Probes for Ultrasensitive Biological Detection and Imaging (pages 71–89): Amit Agrawal, Tushar Sathe and Shuming NieChapter 5 Tailoring Nanoparticles for the Recognition of Biomacromolecule Surfaces (pages 91–117): Mrinmoy De, Rochelle R. Arvizo, Ayush Verma and Vincent M. RotelloChapter 6 Nanoscale Chemical Analysis of Individual Subcellular Compartments (pages 119–140): Gina S. Fiorini and Daniel T. ChiuChapter 7 Ultra Sensitive Time?Resolved Near?IR Fluorescence for Multiplexed Bioanalysis (pages 141–168): Li Zhu and Steven A. SoperChapter 8 Ultrasensitive Microarray Detection of DNA using Enzymatically Amplified SPR Imaging (pages 169–194): Hye Jin Lee, Alastair W. Wark and Robert M. CornChapter 9 Ultrasensitive Analysis of Metal Ions and Small Molecules in Living Cells (pages 195–214): Richard B. ThompsonChapter 10 Electrochemistry Inside and Outside Single Nerve Cells (pages 215–234): Daniel J. Eves and Andrew G. EwingChapter 11 Electrochemiluminescence Detection in Bioanalysis (pages 235–267): Xiao?Hong Nancy Xu and Yanbing ZuChapter 12 Single?Cell Measurements with Mass Spectrometry (pages 269–293): Eric B. Monroe, John C. Jurchen, Stanislav S. Rubakhin and Jonathan V. SweedlerChapter 13 Outlooks of Ultrasensitive Detection in Bioanalysis (pages 295–299): Xiao?Hong Nancy Xu