دانلود کتاب Cholesterol Regulation of Ion Channels and Receptors

Examines new research on the role of cholesterol in regulating ion channels and receptors and its effect on healthDrawing together and analyzing all the latest research findings, this book explores the role of cholesterol in the regulation of ion channels and receptors, including its pathological effects. It is the first book to comprehensively describe the complex mechanisms by which cholesterol regulates two major classes of membrane proteins. Moreover, it sheds new light on how cholesterol affects essential cellular functions such as the contraction of the heart, propagation of nerve impulses, and regulation of blood pressure and kidney function. Written and edited by leading pioneers in the field, Cholesterol Regulation of Ion Channels and Receptors is divided into three parts: Part I, Cholesterol Regulation of Membrane Properties, introduces the heterogeneity of cholesterol distribution in biological membranes and the physical and biological implications of the formation of cholesterol-rich membrane domains.Part II, Cholesterol Regulation of Ion Channels, examines the mechanisms underlying cholesterol sensitivities of ion channels, including the regulation of ion channels by cholesterol as a boundary lipid.Part III, Cholesterol Regulation of Receptors, explores the latest discoveries concerning how cholesterol regulates distinct types of receptors, including G-protein coupled receptors, LDL and scavenger receptors, and innate immune system receptors.Increased levels of cholesterol represent a major health risk. Understanding cholesterol regulation of ion channels and receptors is essential for facilitating the development of new therapeutic strategies to alleviate the impact of pathological cholesterol conditions. With this book as their guide, readers have access to the most current knowledge in the field.Content: Chapter 1 Cholesterol Trafficking and Distribution between Cellular Membranes (pages 1–25): Daniel Wustner, Lukasz Michael Solanko and Frederik W. LundChapter 2 Cholesterol Regulation of Membrane Protein Function by Changes in Bilayer Physical Properties—An Energetic Perspective (pages 27–44): Jens A. Lundb?k and Olaf S. AndersenChapter 3 Insights into Structural Determinants of Cholesterol Sensitivity of Kir Channels (pages 45–67): Avia Rosenhouse?Dantsker and Irena LevitanChapter 4 Role of Lipid Rafts in the Regulation of Store?Operated Ca2+ Channels (pages 69–90): Hwei L. Ong and Indu S. AmbudkarChapter 5 Cholesterol Regulation of Cardiac Ion Channels (pages 91–107): Elise Balse, Stephane Hatem and Stanley NattelChapter 6 Differential Contribution of BK Subunits to Nongenomic Regulation of Channel Function by Steroids (pages 109–134): Alex M. Dopico, Anna N. Bukiya and Aditya K. SinghChapter 7 Regulation of K+ Channels by Cholesterol?Rich Membrane Domains in the Immune System (pages 135–160): Nuria Comes and Antonio FelipeChapter 8 Indirect Channel Regulation by Cholesterol: The Role of Caveolae and Caveolins in Regulating KATP Channel Function (pages 161–179): Caroline DartChapter 9 Regulation of the Nicotinic Acetylcholine Receptor by Cholesterol as a Boundary Lipid (pages 181–204): Francisco J. BarrantesChapter 10 Specific and Nonspecific Regulation of GPCR Function by Cholesterol (pages 205–230): Gerald Gimpl and Katja Gehrig?BurgerChapter 11 Structural Insights into Cholesterol Interactions with G?Protein?Coupled Receptors (pages 231–253): Jeremiah S. Joseph, Enrique E. Abola and Vadim CherezovChapter 12 Membrane Cholesterol: Implications in Receptor Function (pages 255–271): Sandeep Shrivastava and Amitabha ChattopadhyayChapter 13 The Role of Cholesterol and Lipid Rafts in Regulation of TLR Receptors (pages 273–280): Ruxana T. Sadikot