دانلود کتاب Molecular and Biochemical Toxicology, Fourth Edition

An essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionals Over the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels. Now, as the principles and methods of molecular and cellular biology as well as genomic sciences play an ever increasing role in mechanistic toxicology, significant changes have been made to the book, resulting in this important new edition-now titled Molecular and Biochemical Toxicology, Fourth Edition. Much more than an introductory text, this crucial new edition has been completely revised to provide timely and thorough coverage of the underlying biochemical, molecular, and cellular mechanisms through which toxicants produce their adverse effects. Toxicological issues are covered from the molecule to the cell to the organ level. Complex methods used in toxicology are also described in a straightforward, easy-to-understand style. Additional features of this new edition include: New chapters that explore the interface between toxicology and genomic sciences, including: bioinformatics, proteomics, metabolomics, and toxicogenomics Increased emphasis on structure, mechanism, and regulation of xenobiotic metabolizing enzymes, toxicogenetics, and xenobiotic transporters Additional new chapters on: molecular epidemiology and genetic susceptibility, DNA damage and mutagenesis, DNA repair, mechanisms of cell death, mitochondrial dysfunction, metals, reproductive toxicology, developmental toxicology, and reactive oxygen/metabolites and toxicity Molecular and Biochemical Toxicology, Fourth Edition guides graduate students, toxicologists, and environmental health professionals through the principles of molecular and biochemical toxicology and the complex mechanisms of toxicity. Whether it's used in the classroom or in industry, research, or academia, this book is essential for anyone interested in understanding the molecular mechanisms through which toxicants produce adverse effects.Content: Chapter 1 Molecular and Biochemical Toxicology: Definition and Scope (pages 1–4): Ernest Hodgson and Robert C. SmartChapter 2 Overview of Molecular Techniques in Toxicology: Genes and Transgenes (pages 5–24): Robert C. SmartChapter 3 Toxicogenomics (pages 25–39): Marjorie F. OleksiakChapter 4 Proteomics (pages 41–66): B. Alex MerrickChapter 5 Metabolomics (pages 67–79): Nigel DeightonChapter 6 Bioinformatics (pages 81–107): Eric A. Stone and Dahlia M. NielsenChapter 7 Immunochemical Techniques in Toxicology (pages 109–127): Gerald A. LeBlancChapter 8 Cellular Techniques (pages 129–145): Sharon A. MeyerChapter 9 Structure, Mechanism, and Regulation of Cytochromes P450 (pages 147–172): Darryl C. Zeldin and John M. SeubertChapter 10 Phase 1 Metabolism of Toxicants and Metabolic Interactions (pages 173–203): Ernest Hodgson, Parikshit C. Das, Taehyeon M. Cho and Randy L. RoseChapter 11 Phase I—Toxicogenetics (pages 205–218): Ernest Hodgson and Edward L. CroomChapter 12 Phase II—Conjugation of Toxicants (pages 219–237): Gerald A. LeBlancChapter 13 Regulation and Polymorphisms in Phase II Genes (pages 239–256): Yoshiaki TsujiChapter 14 Developmental Effects on Xenobiotic Metabolism (pages 257–272): Martin J. J. Ronis and Helen C. CunnyChapter 15 Cellular Transport and Elimination (pages 273–285): David S. MillerChapter 16 Mechanisms of Cell Death (pages 287–318): Mac Law and Susan ElmoreChapter 17 Mitochondrial Dysfunction (pages 319–332): Jun Ninomiya?TsujiChapter 18 Glutathione?Dependent Mechanisms in Chemically Induced Cell Injury and Cellular Protection Mechanisms (pages 333–358): Donald J. ReedChapter 19 Toxicant–Receptor Interactions: Fundamental Principles (pages 359–388): Richard B. MailmanChapter 20 Reactive Oxygen/Reactive Metabolites and Toxicity (pages 389–411): Elizabeth L. MackenzieChapter 21 Metals (pages 413–439): David B. BuchwalterChapter 22 DNA Damage and Mutagenesis (pages 441–491): Zhigang WangChapter 23 DNA Repair (pages 493–535): Isabel MellonChapter 24 Carcinogenesis (pages 537–586): Robert C. Smart, Sarah J. Ewing and Kari D. LoomisChapter 25 Genetic Toxicology (pages 587–606): R. Julian PrestonChapter 26 Molecular Epidemiology and Genetic Susceptibility (pages 607–637): Ruth M. Lunn and Mariana C. SternChapter 27 Respiratory Toxicity (pages 639–670): James C. BonnerChapter 28 Hepatotoxicity (pages 671–692): Andrew D. Wallace and Sharon A. MeyerChapter 29 Biochemical Mechanisms of Renal Toxicity (pages 693–724): Joan B. Tarloff and Andrew D. WallaceChapter 30 Biochemical Toxicology of the Peripheral Nervous System (pages 725–741): Jeffry F. Goodrum, Arrel D. Toews and Thomas W. BouldinChapter 31 Biochemical Toxicology of the Central Nervous System (pages 743–764): Bonita L. BlakeChapter 32 Immunotoxicity (pages 765–803): Maryjane K. Selgrade, Dori R. Germolec, Robert W. Luebke, Ralph J. Smialowicz, Marsha D. Ward and Christal C. BowmanChapter 33 Reproductive Toxicology (pages 805–830): John F. CouseChapter 34 Developmental Toxicology (pages 831–849): John F. CouseChapter 35 Dermatotoxicology (pages 851–880): Nancy A. Monteiro?Riviere