دانلود کتاب Chronopharmaceutics: Science and Technology for Biological Rhythm-Guided Therapy and Prevention of Diseases

ChronopharmaceuticsScience and Technology for Biological Rhythm Guided Therapy and Prevention of Diseases Edited by Bi-Botti C. Youan The first standard reference on chronopharmaceutics As we better understand how biological processes unfold in real time through advances in chronobiology and related fields, we can create safer, more effective drugs, drug delivery systems, and disease monitoring and prevention systems. When administered in correct coordination with a patient's body rhythms, such drugs can maximize therapeutic outcome while minimizing unwanted side effects. Chronopharmaceutics presents the first standard reference text on this emerging cross-disciplinary field and its potential for therapeutic and preventive medicine. Bringing together the latest findings from experienced investigators, this edited work presents a much-needed single source on chronopharmaceutics. After an introduction that includes a timeline of key discoveries, an overview of regula-tory, formulation, manufacturing and key resource issues associated with chronopharmaceutics, the detailed coverage examines: ChronogeneticsChronopharmacokineticsChronotherapyControlled release systems triggered by physical and/or chemical activationChronopharmacodynamics, chronomics, and anesthesiaMarkers-guided chronotheranosticsFilling a gap in both the graduate classroom and the working industrial or research laboratory, Chronopharmaceutics offers students, instructors, and professionals a unique and comprehensive reference for this cutting-edge field.Content: Chapter 1 Overview of Chronopharmaceutics (pages 1–49): Bi?Botti C. YouanChapter 2 Chronogenetics (pages 51–77): Franck DelaunayChapter 3 Chronopharmacokinetics (pages 79–97): Bernard BruguerolleChapter 4 Chemical Oscillator Systems for Chronotherapy (pages 99–119): Steven A. GiannosChapter 5 Diffucaps® Technology for Controlled Release Drug Delivery (pages 121–144): Gopi VenkateshChapter 6 Chronotopic™ Technology (pages 145–163): M. E. Sangalli, A. Maroni, L. Zema, M. Cerea and A. GazzanigaChapter 7 Chronotherapy using Egalet® Technology (pages 165–173): Daniel Bar?Shalom, Clive G. Wilson and Neena WashingtonChapter 8 CHRONSET™: An OROS® Delivery System for Chronotherapy (pages 175–186): Liang C. Dong, Crystal Pollock?Dove and Patrick S. L. WongChapter 9 Controlled Release Microchips (pages 187–215): Karen Daniel, Hong Linh Ho Duc, Michael Cima and Robert LangerChapter 10 Implications and Applications of Circadian Susceptibility Rhythms: Chronomics and Anesthesia (pages 217–255): Franz Halberg, Germaine Cornelissen and Othild SchwartzkopffChapter 11 Treatment with Open Eyes: Markers?Guided Chronotheranostics (pages 257–323): Germaine Cornelissen and Franz Halberg