جزییات کتاب
This handbook and ready reference highlights a couple of basic aspects of recently developed new methods in modern crop protection research, authored by renowned experts from major agrochemical companies. Organized into four major parts that trace the key phases of the compound development process, the first section addresses compound design, while the second covers newly developed methods for the identification of the mode of action of agrochemical compounds. The third part describes methods used in improving the bioavailability of compounds, and the final section looks at modern methods for risk assessment. As a result, the agrochemical developer will find here a valuable toolbox of advanced methods, complete with first-hand practical advice and copious examples from current industrial practice.Content: Chapter 1 High?Throughput Screening in Agrochemical Research (pages 1–20): Mark Drewes, Klaus Tietjen and Thomas C. SparksChapter 2 Computational Approaches in Agricultural Research (pages 21–41): Klaus?Jurgen SchleiferChapter 3 Quantum Chemical Methods in the Design of Agrochemicals (pages 43–71): Michael SchindlerChapter 4 The Unique Role of Halogen Substituents in the Design of Modern Crop Protection Compounds (pages 73–128): Dr. Peter JeschkeChapter 5 RNA Interference (RNAi) for Functional Genomics Studies and as a Tool for Crop Protection (pages 129–160): Bernd Essigmann, Eric Paget and Frederic SchmittChapter 6 Fast Identification of the Mode of Action of Herbicides by DNA Chips (pages 161–173): Peter Eckes and Marco BuschChapter 7 Modern Approaches for Elucidating the Mode of Action of Neuromuscular Insecticides (pages 175–196): Daniel CordovaChapter 8 New Targets for Fungicides (pages 197–216): Klaus Tietjen and Peter H. SchreierChapter 9 New Formulation Developments (pages 217–248): Rolf Pontzen and Arnoldus W. P. VermeerChapter 10 Polymorphism and the Organic Solid State: Influence on the Optimization of Agrochemicals (pages 249–272): Britta Olenik and Gerhard ThielkingChapter 11 The Determination of Abraham Descriptors and Their Application to Crop Protection Research (pages 273–305): Eric D. Clarke and Laura J. MallonChapter 12 Ecological Modeling in Pesticide Risk Assessment: Chances and Challenges (pages 307–333): Walter SchmittChapter 13 The Use of Metabolomics In Vivo for the Development of Agrochemical Products (pages 335–349): Hennicke G. Kamp, Doerthe Ahlbory?Dieker, Eric Fabian, Michael Herold, Gerhard Krennrich, Edgar Leibold, Ralf Looser, Werner Mellert, Alexandre Prokoudine, Volker Strauss, Tilmann Walk, Jan Wiemer and Bennard van RavenzwaayChapter 14 Safety Evaluation of New Pesticide Active Ingredients: Enquiry?Led Approach to Data Generation (pages 351–379): Paul ParsonsChapter 15 Endocrine Disruption: Definition and Screening Aspects in the Light of the European Crop Protection Law (pages 381–400): Susanne N. Kolle, Burkhard Flick, Tzutzuy Ramirez, Roland Buesen, Hennicke G. Kamp and Bennard van Ravenzwaay