دانلود کتاب Enzyme Technologies: Metagenomics, Evolution, Biocatalysis, and Biosynthesis

An authoritative review of the latest developments in the chemical biology of enzymes In the first decade of the twenty-first century, enzymes and their multiple applications have played a critical role in the discovery and development of many new therapeutic agents.This book is a coordinated compilation of research expertise and current opinion uniquely focused on enzymes and their properties and applications. Compiled by editors with a combined pharmaceutical experience of over sixty years, the text provides in-depth reviews of recent developments in selective topics on biosynthesis, biocatalysis, and chemical biology of enzymes as it applies to drug discovery, development, and manufacture. The first in a multi-part series on enzymes, this volume features three sections: New Approaches to Find and Modify Enzymes describes the emerging field of metagenomics, presents the practical applications of directed evolution to enzymes and pathways, and explores approaches for the discovery and design of biocatalysts Biocatalytic Applications reviews specific applications of different reactions in producing active pharmaceutical ingredients and surveys recent developments employing enzymes in organic synthesis Biosynthetic Applications goes over successful drug discoveries and developments by combinatorial biosynthesis and reviews the application of combinatorial biosynthesis among multiple compatible hosts These timely discussions, which cover everything from chemical biology of enzymes, to the redesign of binding and catalytic specificities of enzymes, make this volume a valuable tool for keeping up to date. As such, it is an important read for researchers, students, and professors in the study of biotechnology, life sciences, biochemistry, enzymology, medicinal chemistry, and natural products.Content: Chapter 1 Functional Metagenomics as a Technique for the Discovery of Novel Enzymes and Natural Products (pages 1–39): Luke A. Moe, Matthew D. McMahon and Michael G. ThomasChapter 2 Directed Enzyme and Pathway Evolution (pages 41–75): Jacob Vick and Claudia Schmidt‐DannertChapter 3 Combining Natural Biodiversity and Molecular‐Directed Evolution to Develop New Industrial Biocatalysts and Drugs (pages 77–98): Laurent Fourage, Céline Ayrinhac, Johann Brot, Christophe Ullmann, Denis Wahler and Jean‐Marie SonetChapter 4 Principles of Enzyme Optimization for the Rapid Creation of Industrial Biocatalysts (pages 99–124): Richard J. Fox and Lori GiverChapter 5 Enzyme Catalysis in the Synthesis of Active Pharmaceutical Ingredients (pages 125–184): Animesh GoswamiChapter 6 Enzymatic Processes for the Production of Pharmaceutical Intermediates (pages 185–198): David Rozzell and Jim LalondeChapter 7 Novel Developments Employing Redox Enzymes: Old Enzymes in New Clothes (pages 199–249): Kurt Faber, Silvia M. Glueck, Birgit Seisser and Wolfgang KroutilChapter 8 Drug Discovery and Development by Combinatorial Biosynthesis (pages 251–283): Matthew A. DeSieno, Carl A. Denard and Huimin ZhaoChapter 9 Reprogramming Daptomycin and A54145 Biosynthesis to Produce Novel Lipopeptide Antibiotics (pages 285–308): Richard H. Baltz, Kien T. Nguyen and Dylan C. AlexanderChapter 10 Pathway and Enzyme Engineering and Applications for Glycodiversification (pages 309–362): Lishan Zhao and Hung‐Wen Liu