دانلود کتاب Endocrine Disrupters: Hazard Testing and Assessment Methods

Endocrine disrupters are chemicals?both man-made and natural?that interfere with the body's endocrine system, potentially resulting in adverse developmental, reproductive, neurological, and immune effects. In recent years, a number of regulatory authorities around the world have drafted or enacted legislation that requires the detection and assessment of the effects of endocrine disrupters on both humans and wildlife. In response, this book provides comprehensive, up-to-date information on the latest tested and proven methods used to detect and assess the environmental hazards posed by endocrine-disrupting chemicals. Endocrine Disrupters is divided into chapters covering each major taxon as well as chapters dedicated to hazard assessment and regulation. The book covers testing methods for all the vertebrate groups and several invertebrate phyla, including: Crustaceans and mollusksInsectsFishAmphibians and reptilesBirds and mammalsMoreover, the book emphasizes practical, ethical testing methods that combine sensitivity, efficiency, statistical power, and reasonable cost. Each chapter is written by one or more international experts in ecotoxicology, offering readers step-by-step guidance for implementing each method based on the latest research and the authors' firsthand laboratory experience. Furthermore, all the chapters have been subjected to a rigorous peer review and edited in light of the reviewers' comments. References at the end of each chapter guide readers to the literature in the field. Endocrine Disrupters is recommended for scientists who need to test chemicals for possible endocrine-disrupting properties. It is also recommended for regulatory authorities who need to decide whether particular chemicals can be safely marketed. Content: Chapter 1 Ecotoxicity Test Methods for Endocrine?Disrupting Chemicals: An Introduction (pages 1–6): Peter MatthiessenChapter 2 Endocrine Disruption in Wildlife: Background, Effects, and Implications (pages 7–58): Dick Vethaak and Juliette LeglerChapter 3 The Regulatory Need for Tests to Detect EDCs and Assess Their Hazards to Wildlife (pages 59–99): Hans?Christian Stolzenberg, Tobias Frische, Vicki L. Dellarco, Gary Timm, Anne Gourmelon, Taisen Iguchi, Flemming Ingerslev and Mike RobertsChapter 4 Techniques for Measuring Endocrine Disruption in Insects (pages 100–115): Lennart WeltjeChapter 5 Crustaceans (pages 116–142): Magnus BreitholtzChapter 6 Endocrine Disruption in Molluscs: Processes and Testing (pages 143–184): Patricia D. McClellan?GreenChapter 7 Using Fish to Detect Endocrine Disrupters and Assess Their Potential Environmental Hazards (pages 185–201): Peter MatthiessenChapter 8 Screening and Testing for Endocrine?Disrupting Chemicals in Amphibian Models (pages 202–244): Daniel B. PickfordChapter 9 Endocrine Disruption and Reptiles: Using the Unique Attributes of Temperature? Dependent Sex Determination to Assess Impacts (pages 245–271): Satomi Kohno and Louis J. GuilletteChapter 10 Birds (pages 272–303): Paul D. Jones, Markus Hecker, Steve Wiseman and John P. GiesyChapter 11 Mammalian Methods for Detecting and Assessing Endocrine?Active Compounds (pages 304–340): M. Sue MartyChapter 12 Application of the OECD Conceptual Framework for Assessing the Human Health and Ecological Effects of Endocrine Disrupters (pages 341–372): Thomas H. Hutchinson, Jenny Odum and Anne GourmelonChapter 13 The Prospects for Routine Testing of Chemicals for Endocrine?Disrupting Properties and Potential Ecological Impacts (pages 373–384): Peter Matthiessen