دانلود کتاب Overcoming Steroid Insensitivity in Respiratory Disease

Written by well-known experts in field, this is the first book dedicated to dealing with the single most challenging management issue in long-term steroid therapy. Overcoming Steroid Insensitivity in Respiratory Disease reviews important new advances in therapeutics and provides the clinician with the most up to date information on one of the most significant therapeutic challenges to effective management of these diseases. This unique book is an invaluable resource for all postgraduate students and specialist physicians in pulmonology allergy and asthma. It is also of interest for workers in biomedical and pharmaceutical research.Content: Chapter 1 Molecular Mechanisms of Glucocorticoid Receptor Action (pages 1–18): Pankaj Bhavsar and Ian M. AdcockChapter 2 Side Effects of Topical and Oral Glucocorticoids (pages 19–38): Heike Schacke, Khusru Asadullah and Wolf?Dietrich DockeChapter 3 Glucocorticoid Receptor Subtypes and Steroid Sensitivity (pages 39–54): Robert H. Oakley and John A. CidlowskiChapter 4 Dissociated Glucocorticoids (pages 55–71): Ian M. AdcockChapter 5 Generalized Glucocorticoid Insensitivity: Clinical Phenotype and Molecular Mechanisms (pages 73–87): Evangelia Charmandari, Tomoshige Kino and George P. ChrousosChapter 6 Corticosteroid Responsiveness in Asthma: Clinical Aspects (pages 89–107): Kian Fan ChungChapter 7 Glucocorticoid?Insensitive Asthma: Molecular Mechanisms (pages 109–124): John W. BloomChapter 8 Cigarette Smoke, Oxidative Stress and Corticosteroid Responsiveness (pages 125–144): Irfan Rahman and David AdenugaChapter 9 Regulation of Glucocorticoid Sensitivity by Macrophage Migration Inhibitory Factor (pages 145–161): Eric F. MorandChapter 10 Steroid?Sparing Strategies: Long?Acting Inhaled ?2?Agonists (pages 163–185): Anna Miller?Larsson and Olof SelroosChapter 11 Steroid?Sparing Strategies: Other Combinations (pages 187–206): Gaetano Caramori, Kazuhiro Ito and Alberto PapiChapter 12 Kinases as Anti?Inflammatory Targets for Respiratory Disease (pages 207–241): Iain KiltyChapter 13 Pharmacokinetic/Pharmacodynamic Factors and Steroid Sensitivity (pages 243–262): Gonther HochhausChapter 14 Improved Lung Deposition: New Inhaler Devices (pages 263–281): Omar S. Usmani