دانلود کتاب Combinatorial Chemistry, 2nd Ed.

"This revolutionary method enables organic and medicinal chemists to synthesize thousands or even millions of potentially interesting compounds in a single reaction sequence. Combined with current methods of high throughput analysis, combinatorial methods have almost completely replaced the traditional step-by-step synthesis of potential drugs." "Retaining its practice-oriented approach, this new edition has been thoroughly updated to reflect developments in parallel synthesis, while a new chapter on screening complements the overview of combinatorial strategy and synthetic methods. The result is a handbook tailored to the needs of the industry, with almost all the authors affiliated with leading pharmaceutical companies."--BOOK JACKET. Read more... Content: Purification principles in high-speed solution-phase synthesis / Steffen Weinbrenner, C. Christoph Tzschucke -- Linkers for solid-phase organic synthesis (SPOS) and combinatorial approaches on solid supports / Willi Bannwarth -- Cyclative cleavage : a versatile concept in solid-phase organic chemistry / Josef Pernerstorfer -- C-C bond-forming reactions / Wolfgang K.-D. Brill, Gianluca Papeo -- Combinatorial synthesis of heterocycles / Eduard R. Felder, Andreas L. Marzinzik -- Polymer-supported reagents : preparation and use in parallel organic synthesis / Berthold Hinzen, Michael G. Hahn -- Encoding strategies for combinatorial libraries / Berthold Hinzen -- Automation and devices for combinatorial chemistry and parallel organic synthesis / Christian Zechel -- Computer-assisted library design / Andreas Dominik -- Assays for high-throughput screening in drug discovery / Christian M. Apfel, Thilo Enderle. Abstract: Combinatorial chemistry is a revolutionary method, which allows you to synthesize millions of compounds within a few steps and in a very short amount of time. Millions of products, e.g. potential drugs, can be analyzed in one go, so that you know very fast if one or a few substances in your product mixture show biological activity. Read more...