دانلود کتاب Pharmaceutical Bioassays: Methods and Applications

The definitive compendium of bioassay procedures and applications A virtual encyclopedia of key bioassay protocols, this up-to-date, essential resource reviews the methods and applications of bioassays that quantify drug activity and evaluate the validity of pharmacological models. Demonstrating the specific ways in which various pharmaceutical bioassays interpret the activity of drug molecules, the book covers the evaluation and screening of drug compounds in a wide spectrum of therapeutic categories. Throughout, the authors use various models to link experimental observations with findings that clarify the effect of drug compounds on cellular biology and measure the pharmacological activity of chemical substances. This provides an important technological platform for successful drug research and clinical therapy, making Pharmaceutical Bioassays an ideal sourcebook for pharmacologists, pharmaceutical and medical researchers, analytical chemists, toxicologists, and students. Just as a fundamental knowledge of pharmaceutical bioassays is vital to understanding how bioactive agents and new drugs are defined, discovered, and developed, so too is this indispensable reference, which: Offers a complete reference on pharmaceutical bioassays and their specific applications in the assessment of therapies for cancer, Alzheimer's, diabetes, epilepsy, inflammation, antimalarials, pharmacogenomics, and other major therapeutic areas Covers bioassays that measure toxicity, including those for chemical toxicity and hepatoxicity—a particularly significant consideration in the development of safe and tolerable medications Highlights clinically relevant methods, ideas, and techniques to support any pharmaceutical researcher Suggests guidelines and systems to enhance communication between pharmacologists, chemists, and biologists Provides an informative analysis of pharmaceutical bioassay technologies and lab applications Content: Chapter 1 Methods and Applications of Anticancer Bioassays (pages 1–21): Shiqi PengChapter 2 Methods and Applications of Antiviral Assays (pages 23–37): Shiqi Peng, Ming Zhao and Chunying CuiChapter 3 Methods and Applications of Antitubercular Assays (pages 39–44): Shiqi Peng, Ming Zhao and Chunying CuiChapter 4 Methods and Applications of Thrombus?Related Assays (pages 45–64): Ming ZhaoChapter 5 Methods and Applications of Anticoagulation Assays (pages 65–86): Ming ZhaoChapter 6 Methods and Applications of Blood Pressure?Related Assays (pages 87–100): Ming ZhaoChapter 7 Methods and Applications of Assays Related to Parkinson's Disease and Graves' Disease (pages 101–123): Shiqi PengChapter 8 Methods and Applications of Alzheimer's Disease Assays (pages 125–144): Shiqi PengChapter 9 Methods and Applications of Antiosteoporosis Assays (pages 145–156): Ming ZhaoChapter 10 Methods and Applications of Immunomodulating Assays (pages 157–185): Shiqi PengChapter 11 Methods and Applications of Anti?Inflammatory Assays (pages 187–204): Ming ZhaoChapter 12 Methods and Applications of Antioxidant Activity Assays (pages 205–221): Shiqi PengChapter 13 Methods and Applications of Analgesic Assays (pages 223–236): Ming ZhaoChapter 14 Methods and Applications of Epilepsy Assays (pages 237–249): Ming Zhao, Shiqi Peng and Guohui CuiChapter 15 Methods and Applications of Diabetes Assays (pages 251–258): Ming Zhao, Shiqi Peng and Guohui CuiChapter 16 Methods and Applications of Assays for Toxins from Microorganisms (pages 259–280): Shiqi PengChapter 17 Methods and Applications of Toxicity Assays for Chemicals (pages 281–323): Shiqi PengChapter 18 Methods and Applications of Hepatoxicity and Hepatoprotective Assays (pages 325–372): Shiqi PengChapter 19 Methods and Applications of Estrogen Assays (pages 373–395): Shiqi PengChapter 20 Methods and Applications of Antimalarial Assays (pages 397–417): Shiqi PengChapter 21 Methods and Applications of Cytogenetic Receptor and Enzyme Assays (pages 419–443): Shiqi Peng