دانلود کتاب Second Primary Cancers and Cardiovascular Disease After Radiation Therapy

This report provides a focused review of the present state of knowledge on the incidence of second cancers and cardiopulmonary effects after medical exposures to ionizing radiation (e.g., cancer radiotherapy). Subjects of major interest and concern in the use of radiation for the therapy of cancer and other health disorders are the potential late effects of second primary cancers (SPC) and cardiovascular disease (CVD). A particular issue of concern is the occurrence of SPCs in patients treated by radiation therapy for primary cancers during childhood. This Report addresses the issue of SPCs and other potential late effects of radiation therapy in a comprehensive manner. It reviews the worldwide epidemiological literature on the occurrence of SPC and CVD among patients receiving radiation therapy for primary cancers. The Report also describes the radiobiological principles, including genetic factors that may underlie the occurrence of SPCs and other diseases among patients who have previously received radiation therapy. The Report also discusses in-depth the potentially beneficial effect of using modern radiation therapy modalities in reducing the risk of SPC and CVD in patients. Content:• Front Matter • Preface • Table of Contents 1. Executive Summary 2. Introduction 3. Radiobiology and Cancer Biology 4. Epidemiologic Methods for Evaluating Risks from Radiation Therapy 5. Modern Radiation Therapy Modalities and Technologies 6. Radiation Therapy: Dosimetry Relevant to Second Primary Cancers and Cardiovascular Effects 7. Second Primary Cancers: Genetic Underpinnings 8. Second Primary Cancer Risks in Patients Receiving Radiation Therapy 9. Second Primary Cancer Sites with Information on Dose-Response Relationships in the Therapeutic Range 10. Cardiovascular Disease in Patients Receiving Radiation Therapy 11. Conclusions and Recommendations • Glossary • Abbreviations, Acronyms and Symbols • References • The NCRP • NCRP Publications