دانلود کتاب Protein-Protein Interactions in Drug Discovery

Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation. The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as cancer, autoimmune disorders and infectious diseases. Tailor-made for the practicing medicinal chemist, this ready reference includes a wide selection of case studies taken straight from the development pipeline of major pharmaceutical companies to illustrate the power and potential of this approach.Content: Chapter 1 Protein–Protein Interactions: An Overview (pages 1–19): Christian OttmanChapter 2 Prediction of Intra? and Interspecies Protein–Protein Interactions Facilitating Systems Biology Studies (pages 21–53): Sylvia Schleker, Seshan Ananthasubramanian, Judith Klein?Seetharaman and Madhavi K. GanapathirajuChapter 3 Modulators of Protein–Protein Interactions: Importance of Three?Dimensionality (pages 55–62): David C. Fry and Sung?Sau SoChapter 4 A Leap into the Chemical Space of Protein–Protein Interaction Inhibitors (pages 63–83): Bruno O. Villoutreix, C. Labbe, David Lagorce, Guillaume Laconde and Olivier SperandioChapter 5 Interactive Technologies for Leveraging the Known Chemistry of Anchor Residues to Disrupt Protein Interactions (pages 85–100): Carlos J. Camacho, David R. Koes and Prof. Dr. Alexander S. DomlingChapter 6 SH3 Domains as Drug Targets (pages 101–128): James Luccarelli, Sam Thompson and Andrew D. HamiltonChapter 7 p53/MDM2 Antagonists: Towards Nongenotoxic Anticancer Treatments (pages 129–163): Kareem Khoury, Tad A. Holak and Prof. Dr. Alexander DomlingChapter 8 Inhibition of LFA?1/ICAM Interaction for the Treatment of Autoimmune Diseases (pages 165–185): Kevin M. Guckian and Daniel M. ScottChapter 9 The PIF Pocket of AGC Kinases: A Target Site for Allosteric Modulators and Protein–Protein Interaction Inhibitors (pages 187–223): Matthias EngelChapter 10 Retosiban and Epelsiban: Potent and Selective Orally Available Oxytocin Antagonists (pages 225–256): Alan D. Borthwick and John LiddleChapter 11 Peptidic Inhibitors of Protein–Protein Interactions for Cell Adhesion Receptors: RGD Peptides and Beyond (pages 257–290): Carlos Mas?Moruno and Horst KesslerChapter 12 REPLACE Strategy for Generating Non?ATP?Competitive Inhibitors of Cell Cycle Protein Kinases (pages 291–304): Campbell McInnes