دانلود کتاب Lead Optimization for Medicinal Chemists: Pharmacokinetic Properties of Functional Groups and Organic Compounds

Small structural modifications can significantly affect the pharmacokinetic properties of drug candidates. This book, written by a medicinal chemist for medicinal chemists, is a comprehensive guide to the pharmacokinetic impact of functional groups, the pharmacokinetic optimization of drug leads, and an exhaustive collection of pharmacokinetic data, arranged according to the structure of the drug, not its target or indication. The historical origins of most drug classes and general aspects of modern drug discovery and development are also discussed. The index contains all the drug names and synonyms to facilitate the location of any drug or functional group in the book.This compact working guide provides a wealth of information on the ways small structural modifications affect the pharmacokinetic properties of organic compounds, and offers plentiful, fact-based inspiration for the development of new drugs. This book is mainly aimed at medicinal chemists, but may also be of interest to graduate students in chemical or pharmaceutical sciences, preparing themselves for a job in the pharmaceutical industry, and to healthcare professionals in need of pharmacokinetic data.Content: Chapter 1 The Drug Discovery Process (pages 1–12): Chapter 2 Lead Optimization (pages 13–32): Chapter 3 Alkanes (pages 33–39): Chapter 4 Alkenes and Alkynes (pages 40–44): Chapter 5 Arenes (pages 45–48): Chapter 6 Halides (pages 49–57): Chapter 7 Azides (page 58): Chapter 8 Nitro Compounds (pages 59–61): Chapter 9 Azo Compounds (pages 62–63): Chapter 10 Triazenes (pages 64–65): Chapter 11 Nitrates and Nitrites (pages 66–67): Chapter 12 N?Nitroso Compounds (pages 68–69): Chapter 13 N?Oxides (page 70): Chapter 14 Alcohols (pages 71–81): Chapter 15 Phenols (pages 82–90): Chapter 16 Ethers (pages 91–95): Chapter 17 Epoxides (page 96): Chapter 18 Peroxides (page 97): Chapter 19 Thiols (pages 98–99): Chapter 20 Thioethers (pages 100–103): Chapter 21 Sulfoxides (pages 104–105): Chapter 22 Sulfones (page 106): Chapter 23 Aliphatic Amines (pages 107–117): Chapter 24 Quaternary Ammonium Salts (pages 118–119): Chapter 25 Amidines (pages 120–121): Chapter 26 Guanidines, Acylguanidines, and Biguanides (pages 122–132): Chapter 27 Anilines (pages 133–136): Chapter 28 Hydrazines, Acylhydrazines, and Hydrazones (page 137): Chapter 29 Aldehydes (page 138): Chapter 30 Ketones (pages 139–143): Chapter 31 Carboxylic Acids (pages 144–163): Chapter 32 Carboxylic Esters (pages 164–165): Chapter 33 Amides (pages 166–171): Chapter 34 Lactams and Imides (pages 172–183): Chapter 35 Nitriles (pages 184–185): Chapter 36 Carbonates (page 186): Chapter 37 Carbamates (pages 187–191): Chapter 38 Ureas (pages 192–200): Chapter 39 Thiocarbonyl Compounds (pages 201–202): Chapter 40 Sulfonic Acids (pages 203–205): Chapter 41 Sulfonic Esters (page 206): Chapter 42 Sulfates and Sulfamic Acids (pages 207–208): Chapter 43 Phosphonic Acids (pages 209–212): Chapter 44 Phosphoric Acid Derivatives (pages 213–214): Chapter 45 N?(Aminoalkyl)benzamides, ?Benzoates, and Related Compounds (pages 215–224): Chapter 46 Arylalkylamines (pages 225–266): Chapter 47 Phenethylamines (2?Phenylethylamines) (pages 267–290): Chapter 48 Aminoalkylindoles and Indole Alkaloids (pages 291–300): Chapter 49 Phenothiazines (pages 301–309): Chapter 50 Dibenzazepines and Related Tricyclic Compounds (pages 310–319): Chapter 51 3?Aryloxy?2?Hydroxypropylamines (??Adrenergic Antagonists; “??Blockers”) (pages 320–328): Chapter 52 Opiates (pages 329–334): Chapter 53 N?(Carboxyalkyl)???Amino Acid Amides (Prils) (pages 335–340): Chapter 54 Anilides and Amides of Glycine (pages 341–346): Chapter 55 Peptides, Peptidomimetics, and Related Oligoamides (pages 347–364): Chapter 56 Oligoarylamines, Oligoarylamides, Oligoarylcarbamates, and Oligoarylureas (pages 365–376): Chapter 57 Imidazoles (pages 377–386): Chapter 58 Triazoles (pages 387–392): Chapter 59 Pyridines, Pyrimidines, and Related Compounds (pages 393–411): Chapter 60 Quinolines (pages 412–427): Chapter 61 Nucleoside Analogs (pages 428–445): Chapter 62 Dihydropyridines (pages 446–449): Chapter 63 Arenesulfonamides (pages 450–461): Chapter 64 Sulfonylureas (pages 462–465): Chapter 65 Benzodiazepines (pages 466–476): Chapter 66 Steroids (pages 477–491): Chapter 67 Anthracyclines (pages 492–496): Chapter 68 Arylacetic, Benzoic, and Related Carboxylic Acids (NSAIDS) (pages 497–513): Chapter 69 Quinolonecarboxylic Acids (Gyrase Inhibitors) (pages 514–521): Chapter 70 ??Lactams (pages 522–537): Chapter 71 Prostaglandin Analogs (pages 538–542): Chapter 72 Sartans (pages 543–547): Chapter 73 Statins (pages 548–550): Chapter 74 Folic Acid Analogs (Antifolates) (pages 551–553): Chapter 75 Taxanes (pages 554–556): Chapter 76 Macrocyclic Compounds (pages 557–565):