دانلود کتاب Mycobacteria: Molecular Biology and Virulence

Tuberculosis continues to kills more people than any other single infective agent. The resurgence of the disease in many countries has produced a heightened awareness of the threat posed by mycobacterial infections. At the same time, there has been an explosion of knowledge of the fundamental properties of mycobacteria, most notably the determination of the complete genome sequence of Mycobacterium tuberculosis. This book provides an up-to-date account of these developments in the molecular biology and immunology of mycobacteria, coupled with allied advances of a more applied nature, such as the use of molecular techniques for diagnosis and epidemiological investigations. With chapters contributed from an international team of experts, it will not only be an essential reference text for the expanding mycobacterial research community, but also will find a prominent place on the shelves of clinicians, infectious disease and public health specialists, diagnostic laboratories, postgraduate students and indeed anyone concerned with the management and investigation of outbreaks of tuberculosis. Comprehensively covers recent advances in the molecular biology of the mycobacteria. First book to be published on this subject since the publishing of the complete genome for the tubercle bacillus (M. tuberculosis). Coincides with a worldwide resurgence of tuberculosis.Content: Chapter 1 Recombination (pages 1–16): Graham R. Stewart and Johnjoe McFaddenChapter 2 Mobile Genetic Elements and Plasmids: Tools for Genetic Studies (pages 17–37): Christophe Guilhot, Mary Jackson and Brigitte GicquelChapter 3 Mycobacteriophages (pages 38–58): Graham F. HatfullChapter 4 Gene Expression and Regulation (pages 59–92): Juliano Timm, Manuel Gomez and Issar SmithChapter 5 Genomics of Mycobacterium Tuberculosis and Mycobacterium Leprae (pages 93–109): Stephen V. Gordon, Karin Eiglmeier, Roland Brosch, Thierry Garnier, Nadine Honore, Bart G. Barrell and Stewart T. ColeChapter 6 Molecular Epidemiology: Human Tuberculosis (pages 110–122): Paul van HeldenChapter 7 Molecular Epidemiology: Mycobacterium Bovis (pages 123–135): Desmond M. CollinsChapter 8 Molecular Epidemiology: Other Mycobacteria (pages 136–160): Joseph O. FalkinhamChapter 9 Molecular Diagnostics (pages 161–179): Kathleen D. EisenachChapter 10 Immunodiagnosis of Mycobacterial Infection (pages 180–197): Graham H. Bothamley, David Catty, Richard Clifton?Hadley, Frank Griffin, Glyn Hewinson and John PollockChapter 11 Mycobacterial Growth and Dormancy (pages 198–219): M. Joseph Colston and Robert A. CoxChapter 12 Cell Wall: Physical Structure and Permeability (pages 220–239): Jun Liu, Clifton E. Barry and Hiroshi NikaidoChapter 13 The Cell?Wall Core of Mycobacterium: Structure, Biogenesis and Genetics (pages 240–259): Alain R. Baulard, Gurdyal S. Besra and Patrick J. BrennanChapter 14 Iron Metabolism (pages 260–286): Colin RatledgeChapter 15 Antibiotics and Antibiotic Resistance in Mycobacteria (pages 287–306): Vera Webb and Julian DaviesChapter 16 Immunotherapy for Mycobacterial Diseases (pages 307–334): John L. Stanford and Graham A. W. RookChapter 17 Vaccines (pages 335–355): Douglas B. LowrieChapter 18 Mycobacterial Antigens (pages 356–370): Jelle Thole, Riny Janssen and Douglas YoungChapter 19 Mycobacterium and the Seduction of the Macrophage (pages 371–388): David G. RussellChapter 20 Cytokines in Immunity to Tuberculosis (pages 389–397): Andrea M. Cooper and Ian M. Orme