دانلود کتاب Modern Biopharmaceuticals: Recent Success Stories

This collection of high-profile contributions provides a unique insight into the development of novel, successful biopharmaceuticals. Outstanding authors, including Nobel laureate Robert Huber as well as prominent company researchers and CEOs, present valuable insider knowledge, limiting their scope to those procedures and developments with proven potential for the biotechnology industry. They cover all relevant aspects, from the establishment of biotechnology parks, the development of successful compounds and the implementation of efficient manufacturing processes, right up to the establishment of advanced delivery routes.Content: Chapter 1 Twenty Thousand Years of Biotech – From “Traditional” to “Modern Biotechnology” (pages 1–38): Jorg KnableinChapter 2 Induced Pluripotency as Substitute of Somatic Cell Nuclear Transfer? – The Impact of Induced Pluripotent Stem Cells on Drug Discovery and Regenerative Biopharmaceuticals (pages 39–55): Rita P. Cervera and Miodrag StojkovicChapter 3 Pluripotent Stem Cell?Derived Cardiomyocytes for Industrial and Clinical Applications (pages 57–76): James E. Hudson, Peter Christalla and Wolfram?Hubertus ZimmermannChapter 4 Industrialization of Functional Mouse Genomics Technologies for Biopharmaceutical Drug Discovery and Development (pages 77–91): Peter Stadler, Jost Seibler and Frieder SchwenkChapter 5 Standardized Solutions for Quantitative and Real?Time RT?PCR to Accelerate Biopharmaceutical Development (pages 93–113): Dirk LoffertChapter 6 Massive Mutagenesis®: The Path to Smarter Genetic Libraries (pages 115–134): Julien Sylvestre, Stephane Blesa, Ingrid Marchal, Philippe Thullier, Olivier Dubreuil and Marc DelcourtChapter 7 Cut & Go – FastDigest® with All Restriction Enzymes @ Same Temperature and Buffer: A New Paradigm in DNA Digestion to Speed?Up Biopharmaceutical Development (pages 135–146): Arvydas JanulaitisChapter 8 StarGate®: A High?Capacity Expression Cloning System to Speed?Up Biopharmaceutical Development (pages 147–164): Uwe D. Carl, Lilia Batz, Isabel Schuchardt, Lothar Germeroth and Thomas G. M. SchmidtChapter 9 Precision Genome Surgery with Meganucleases: A Promising Biopharmaceutical for Gene Therapy (pages 165–181): Alfred Pingoud, George H. Silva and Wolfgang WendeChapter 10 Innovative Diagnostics Enhances and Advances the Impact of In Vivo Small?Animal Imaging in Drug Discovery and Pharmaceutical Development (pages 183–209): Andreas BrielChapter 11 Revolutionizing Biopharmaceutical Development with Quantitative Multispectral Optoacoustic Tomography (MSOT) (pages 211–232): Vasilis Ntziachristos and Daniel RazanskyChapter 12 Pharma Research Biobanking: Need, Socioethical Considerations, and Best Practice (pages 233–247): Janine Swifka, Khusru Asadullah and Arndt A. P. SchmitzChapter 13 Implementation of Advanced Technologies in Commercial Monoclonal Antibody Production (pages 249–284): Joe X. Zhou, Tim Tressel, Xiaoming Yang and Thomas SeewoesterChapter 14 A Real Success Story: Plantibodies for Human Therapeutic Use (pages 285–295): Dr. Jorg Knablein, Merardo Pujol and Carlos BorrotoChapter 15 A Modern Biopharmaceutical to Treat AIDS – Challenges in Designing HIV Env Immunogens for Developing a Vaccine (pages 297–347): Zohar Biron and Indresh K. SrivastavaChapter 16 Accelerated Biopharmaceutical Development: Vero Cell Technology and Pandemic Influenza Vaccine Production (pages 349–386): P. Noel Barrett, Daniel Portsmouth and Hartmut J. EhrlichChapter 17 BioBenchmarking: The Global Perspective to Ensure Future Success of Biopharmaceutical Development (pages 387–400): Pete CaldwellChapter 18 Basic Concepts for the Development of a Biosimilar Product: Experience with Omnitrope®, the First Ever Approved Similar Biopharmaceutical Product (pages 401–428): Alexander Berghout, Andreas Premstaller and Mark McCamishChapter 19 Recombinant Factor VIII (Kogenate®) for the Treatment of Hemophilia A: The First and Only World?Wide Licensed Recombinant Protein Produced in High?Throughput Perfusion Culture (pages 429–443): Berthold G. D. BoedekerChapter 20 Posttranslational Modifications to Improve Biopharmaceuticals (pages 445–467): Gary WalshChapter 21 The Development of Biomaterials for Delivery of Nucleic Acid Therapeutics (pages 469–485): Fan Yang, Michael Goldberg, Robert Langer and Daniel G. AndersonChapter 22 Bright Future Outlook and Huge Challenges to Overcome: An Attempt to Write the Short Story of the Biopharma Industry with Current Status, Selected Issues, and Potential Solutions in Discovery, R&D, and Manufacturing (pages 487–526): Gunter JagschiesChapter 23 Large?Scale Manufacturing of Biopharmaceuticals – Speed Up the Road to Market by Scale Up: the 6 ? 15 000 l BI Bioreactors (pages 527–537): Andreas WernerChapter 24 Reliable, Large?Scale Cleavage of Tags from Affinity?Purified Biopharmaceuticals (pages 539–557): Conni Lauritzen, Gitte E. Nygaard, John Pedersen, Jose Arnau, Ulla Romer and Frank SchaferChapter 25 In Situ On?Line Monitoring of Fermentation Processes: A Cool Tool for Biopharmaceutical Production (pages 559–616): Oscar Reif, Reinhard Baumfalk and Ina PahlChapter 26 Queen Honeybee and Me: Forever Young? Conserved Pathways for Longevity (pages 617–702): Dr. Jorg Knablein and Robert Huber