دانلود کتاب Alternative Splicing and Disease

Name: Alternative Splicing and Disease
Availability: InStock
Author: Laurent Bracco
ISBN: 9783540344483, 9783540344490

by Laurent Bracco

عنوان فارسی: پیرایش جایگزین و بیماری
ناشر: Springer-Verlag Berlin Heidelberg
سال: 2006
ویرایش: 1
زبان: انگلیسی
تعداد صفحه (نسخه چاپی - نسخه الکترونیکی): 257-264
شابک: 9783540344483, 9783540344490
نوع فایل: PDF دانلود نرم افزار مطالعه
حجم: 2.00 مگابایت

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جزییات کتاب

Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative splicing of a given transcript can therefore yield several distinct mRNAs encoding as many different proteins. Its full biological significance has not been appreciated until it was recognized that alternative splicing is so general as to affect about 75% of all human genes. Therefore, alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.

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